Structural Properties of AMP-activated Protein Kinase (Q57090919)

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4 January 2020

title

Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding (English)

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Dietbert Neumann

10

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Dmitri Svergun

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Uwe Schlattner

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Theo Wallimann

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Uwe Riek

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author name string

Peter Konarev

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Arne Rufer

4

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Marianne Suter

5

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Alexis Nazabal

6

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Philippe Ringler

7

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Mohamed Chami

8

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Michael Forstner

11

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Michael Hennig

12

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Renato Zenobi

13

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Andreas Engel

14

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Shirley A Müller

9

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language of work or name

English

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publication date

27 March 2008

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Journal of Biological Chemistry

4 January 2020

published in

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volume

283

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issue

26

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page(s)

18331-18343

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

4 January 2020

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

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Energy-dependent regulation of cell structure by AMP-activated protein kinase

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Signaling by AMP-activated Protein Kinase

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

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Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

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The AMP-activated protein kinase--fuel gauge of the mammalian cell?

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AMP-activated protein kinase: the energy charge hypothesis revisited

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

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AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270)

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A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits

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A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.

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AMPK beta subunit targets metabolic stress sensing to glycogen

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Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization

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AMPK: a key sensor of fuel and energy status in skeletal muscle

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

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New roles for the LKB1-->AMPK pathway.

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Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

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AMP-activated protein kinase protects against anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death

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Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis

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AMPK, the metabolic syndrome and cancer

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AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

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Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits.

21 January 2018

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M708379200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18372250%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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