New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B (Q57201013)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18348677%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

review article

1 reference

title

New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B (English)

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4 January 2020

2

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4 January 2020

author name string

Yina H Huang

series ordinal

1

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4 January 2020

Karsten Sauer

series ordinal

3

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4 January 2020

language of work or name

English

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publication date

1 April 2008

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Expert Opinion on Therapeutic Targets

4 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18348677%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

12

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4 January 2020

issue

4

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4 January 2020

page(s)

391-413

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T cell-directed therapies: lessons learned and future prospects

4 January 2020

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The families of kinases removing the Ca2+ releasing second messenger Ins(1,4,5)P3.

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21 January 2018

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Characterization of the Pleckstrin Homology Domain of Btk as an Inositol Polyphosphate and Phosphoinositide Binding Domain

21 January 2018

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Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Itk and Th2 responses: action but no reaction

21 January 2018

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

21 January 2018

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Orai1 is an essential pore subunit of the CRAC channel

21 January 2018

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CRACM1 multimers form the ion-selective pore of the CRAC channel.

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STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

21 January 2018

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21 January 2018

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Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

21 January 2018

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Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

21 January 2018

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Orai1 and STIM reconstitute store-operated calcium channel function

21 January 2018

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21 January 2018

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Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels

21 January 2018

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STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels

21 January 2018

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Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 January 2018

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Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway

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Herpes simplex virus encephalitis in human UNC-93B deficiency

21 January 2018

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Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

21 January 2018

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

21 January 2018

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Autoantibodies make a U-turn: the toll hypothesis for autoantibody specificity

21 January 2018

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Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

21 January 2018

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

21 January 2018

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Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

21 January 2018

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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

21 January 2018

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Illuminating autoimmune regulators through controlled variation of the mouse genome sequence

21 January 2018

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21 January 2018

FOXP3: of mice and men.

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Genetic background and the dilemma of translating mouse studies to humans

21 January 2018

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Vagaries of conditional gene targeting

21 January 2018

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Cellular and genetic mechanisms of self tolerance and autoimmunity

21 January 2018

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Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice

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https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Can open-source R&D reinvigorate drug research?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

High-throughput electronic biology: mining information for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Positive and negative selection of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Calcineurin B1 is essential for positive but not negative selection during thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Structure of Type IIβ Phosphatidylinositol Phosphate Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Alpha-kinases: analysis of the family and comparison with conventional protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

Genomics: Guilt by association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.4.391

10.1517/14728222.12.4.391

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18348677%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference