Intelligent nucleic acid delivery systems based on stimuli-responsive polymers (Q57363419)

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Yang Wang

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Rui Zhang

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Zi-Chen Li

Gene therapy for human genetic disease?

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publication date

2010

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published in

Soft Matter

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volume

6

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issue

5

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page(s)

835-848

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cites work

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A brief history of gene therapy

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The future of gene therapy

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Gene medicines: the end of the beginning?

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Non-viral siRNA delivery to the lung

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Knocking down barriers: advances in siRNA delivery

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Utilizing RNA interference to enhance cancer drug discovery

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Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

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The promises and pitfalls of RNA-interference-based therapeutics

21 January 2018

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Nonviral methods for siRNA delivery

21 January 2018

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Concepts in in vivo siRNA delivery for cancer therapy

21 January 2018

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RNAi therapeutics: principles, prospects and challenges

21 January 2018

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Nonviral delivery of synthetic siRNAs in vivo

21 January 2018

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Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

21 January 2018

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Non-viral is superior to viral gene delivery.

21 January 2018

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Barriers to successful delivery of short interfering RNA after systemic administration

21 January 2018

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siRNA delivery systems for cancer treatment

21 January 2018

1 reference

Nonviral vectors for gene delivery

21 January 2018

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Gene therapy progress and prospects: synthetic polymer-based systems.

21 January 2018

1 reference

Biodegradable polymers as non-viral carriers for plasmid DNA delivery

21 January 2018

1 reference

Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction

21 January 2018

1 reference

Efficient siRNA delivery with non-viral polymeric vehicles

21 January 2018

1 reference

siRNA conjugate delivery systems

21 January 2018

1 reference

Cationic lipids and polymers mediated vectors for delivery of siRNA.

21 January 2018

1 reference

State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers.

21 January 2018

1 reference

The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic.

21 January 2018

1 reference

Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery

21 January 2018

1 reference

Delivery of RNA interference therapeutics using polycation-based nanoparticles

21 January 2018

1 reference

Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA.

21 January 2018

1 reference

Engineered nanoscaled polyplex gene delivery systems

21 January 2018

1 reference

A review of stimuli-responsive nanocarriers for drug and gene delivery

21 January 2018

1 reference

Multifunctional and stimuli-sensitive pharmaceutical nanocarriers

21 January 2018

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Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery

21 January 2018

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Responsive polymers in controlled drug delivery

21 January 2018

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Thermo- and pH-responsive polymers in drug delivery

21 January 2018

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Conjugates of stimuli-responsive polymers and proteins

21 January 2018

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Breaking the bonds: non-viral vectors become chemically dynamic

21 January 2018

1 reference

Intelligent polymers as nonviral vectors

21 January 2018

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Reduction-sensitive polymers and bioconjugates for biomedical applications

21 January 2018

1 reference

Artificial viruses: a nanotechnological approach to gene delivery

21 January 2018

1 reference

Nanoparticles as nonviral gene delivery vectors

21 January 2018

1 reference

Delivery of siRNA mediated by histidine-containing reducible polycations.

21 January 2018

1 reference

Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA.

21 January 2018

1 reference

Functional polymers for targeted delivery of nucleic acid drugs

21 January 2018

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Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity

21 January 2018

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Toxicity of cationic lipids and cationic polymers in gene delivery

21 January 2018

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A novel biodegradable gene carrier based on polyphosphoester

21 January 2018

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Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery.

21 January 2018

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Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities

21 January 2018

1 reference

21 January 2018

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Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors

21 January 2018

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Self-assembly of DNA-polymer complexes using template polymerization

21 January 2018

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Vectors based on reducible polycations facilitate intracellular release of nucleic acids

21 January 2018

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A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids

21 January 2018

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Highly branched HK peptides are effective carriers of siRNA.

21 January 2018

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Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine

21 January 2018

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Self-crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA.

21 January 2018

1 reference

Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.

21 January 2018

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Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides

21 January 2018

1 reference

Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle

21 January 2018

1 reference

A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity

21 January 2018

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Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine

21 January 2018

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A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.

21 January 2018

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Biodegradable poly(ethylenimine) for plasmid DNA delivery

21 January 2018

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Gene carriers based on hexanediol diacrylate linked oligoethylenimine: effect of chemical structure of polymer on biological properties

21 January 2018

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Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers

21 January 2018

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Polyethylenimine with acid-labile linkages as a biodegradable gene carrier.

21 January 2018

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Acetal linked oligoethylenimines for use as pH-sensitive gene carriers

21 January 2018

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An acid sensitive ketal-based polyethylene glycol-oligoethylenimine copolymer mediates improved transfection efficiency at reduced toxicity

21 January 2018

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Influence of disulfide density and molecular weight on disulfide cross-linked polyethylenimine as gene vectors

21 January 2018

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The influence of RGD addition on the gene transfer characteristics of disulfide-containing polyethyleneimine/DNA complexes

21 January 2018

1 reference

The development and characterization of a glutathione-sensitive cross-linked polyethylenimine gene vector.

21 January 2018

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Poly(ethylenimine-co-L-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery

21 January 2018

1 reference

Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo

21 January 2018

1 reference

Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system

21 January 2018

1 reference

Breaking up the correlation between efficacy and toxicity for nonviral gene delivery

21 January 2018

1 reference

Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo.

21 January 2018

1 reference

Effect of chemical functionalities in poly(amido amine)s for non-viral gene transfection

21 January 2018

1 reference

Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery

21 January 2018

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Reducible poly(amido ethylenimine) directed to enhance RNA interference

21 January 2018

1 reference

Cardiomyocyte-targeted siRNA delivery by prostaglandin E(2)-Fas siRNA polyplexes formulated with reducible poly(amido amine) for preventing cardiomyocyte apoptosis

21 January 2018

1 reference

VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine).

21 January 2018

1 reference

Akt1 silencing efficiencies in lung cancer cells by sh/si/ssiRNA transfection using a reductable polyspermine carrier

21 January 2018

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Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions

21 January 2018

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Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA.

21 January 2018

1 reference

Reducible poly(2-dimethylaminoethyl methacrylate): synthesis, cytotoxicity, and gene delivery activity

21 January 2018

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In vivo gene transfer using sulfhydryl cross-linked PEG-peptide/glycopeptide DNA co-condensates

21 January 2018

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Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery

21 January 2018

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Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression

21 January 2018

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Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery

21 January 2018

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Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking

21 January 2018

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Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo

21 January 2018

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Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction

21 January 2018

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

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Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate.

21 January 2018

1 reference

Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide

21 January 2018

1 reference

PEG conjugated VEGF siRNA for anti-angiogenic gene therapy

21 January 2018

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Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer

21 January 2018

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Reversible siRNA-polymer conjugates by RAFT polymerization

21 January 2018

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Knocking (anti)-sense into cells: the microsphere approach to gene silencing.

21 January 2018

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siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters

21 January 2018

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Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes

21 January 2018

1 reference

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

21 January 2018

1 reference

Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase

21 January 2018

1 reference

PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.

21 January 2018

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Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels

21 January 2018

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PEG-assisted DNA solubilization in organic solvents for preparing cytosol specifically degradable PEG/DNA nanogels

21 January 2018

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Gene delivery through the use of a hyaluronate-associated intracellularly degradable crosslinked polyethyleneimine

21 January 2018

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Bioreducible hyperbranched poly(amido amine)s for gene delivery

21 January 2018

1 reference

Recent progress in tumor pH targeting nanotechnology

21 January 2018

1 reference

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

21 January 2018

1 reference

The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes

21 January 2018

1 reference

Rational design of composition and activity correlations for pH-sensitive and glutathione-reactive polymer therapeutics

21 January 2018

1 reference

pH-responsive poly(styrene-alt-maleic anhydride) alkylamide copolymers for intracellular drug delivery

21 January 2018

1 reference

Development of a novel endosomolytic diblock copolymer for siRNA delivery

21 January 2018

1 reference

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

1 reference

Histidine-rich peptides and polymers for nucleic acids delivery

21 January 2018

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Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity

21 January 2018

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Quantum dot-amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA.

21 January 2018

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Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging

21 January 2018

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Sheddable coatings for long-circulating nanoparticles

21 January 2018

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pH-responsive shielding of non-viral gene vectors.

21 January 2018

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Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo

21 January 2018

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An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes

21 January 2018

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An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems

21 January 2018

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pH-responsive Multi-PEGylated dual cationic nanoparticles enable charge modulations for safe gene delivery.

21 January 2018

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Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles

21 January 2018

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pH-triggered reversible "stealth" polycationic micelles.

21 January 2018

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pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study

21 January 2018

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A biodegradable pH-sensitive micelle system for targeting acidic solid tumors

21 January 2018

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Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery

21 January 2018

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Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules

21 January 2018

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Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery.

21 January 2018

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Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery

21 January 2018

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

21 January 2018

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Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine

21 January 2018

1 reference

Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery

21 January 2018

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pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation

21 January 2018

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Novel intracellular delivery system of antisense oligonucleotide by self-assembled hybrid micelles composed of DNA/PEG conjugate and cationic fusogenic peptide.

21 January 2018

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Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages.

21 January 2018

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Folate receptor targeted delivery of polyelectrolyte complex micelles prepared from ODN-PEG-folate conjugate and cationic lipids

21 January 2018

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Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.

21 January 2018

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Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes.

21 January 2018

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Site-specific delivery of oligonucleotides to hepatocytes after systemic administration.

21 January 2018

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Gene expression control by temperature with thermo-responsive polymeric gene carriers

21 January 2018

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Temperature-Controlled Behavior of Self-Assembly Gene Delivery Vectors Based on Complexes of DNA with Poly(l-lysine)-graft-poly(N-isopropylacrylamide)

21 January 2018

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Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors

21 January 2018

1 reference

A thermoresponsive chitosan-NIPAAm/vinyl laurate copolymer vector for gene transfection

21 January 2018

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The gene transfection efficiency of thermoresponsive N,N,N-trimethyl chitosan chloride-g-poly(N-isopropylacrylamide) copolymer

21 January 2018

1 reference

A study of thermoresponsive poly(N-isopropylacrylamide)/polyarginine bioconjugate non-viral transgene vectors

21 January 2018

1 reference

Temperature-sensitive pluronic/poly(ethylenimine) nanocapsules for thermally triggered disruption of intracellular endosomal compartment.

21 January 2018

1 reference

Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: swelling induced physical disruption of endosome by cold shock.

21 January 2018

1 reference

Peptide-functionalized nanogels for targeted siRNA delivery.

21 January 2018

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Temperature dependent gene expression induced by PNIPAM-based copolymers: potential of hyperthermia in gene transfer

21 January 2018

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Hyperthermia-induced targeting of thermosensitive gene carriers to tumors

21 January 2018

1 reference

Magnetothermally-responsive nanomaterials: combining magnetic nanostructures and thermally-sensitive polymers for triggered drug release

21 January 2018

1 reference

Photodynamic therapy for cancer

21 January 2018

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Photochemical internalization: a new tool for drug delivery.

21 January 2018

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Delivery of siRNA to the target cell cytoplasm: photochemical internalization facilitates endosomal escape and improves silencing efficiency, in vitro and in vivo

21 January 2018

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Optically triggered release of DNA from multivalent dendrons by degrading and charge-switching multivalency.

21 January 2018

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Light-regulated electrostatic interactions in colloidal suspensions

21 January 2018

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Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates

21 January 2018

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Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles.

21 January 2018

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Delivery of siRNA into the cytoplasm by liposomal bubbles and ultrasound

21 January 2018

1 reference

Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles.

21 January 2018

1 reference

Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.

21 January 2018

1 reference

Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus

21 January 2018

1 reference

HPMA polymer-based site-specific delivery of oligonucleotides to hepatic stellate cells

21 January 2018

1 reference

Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

21 January 2018

1 reference

Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate.

21 January 2018

1 reference

Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery

21 January 2018

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Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice

21 January 2018

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Functional delivery of siRNA in mice using dendriworms

21 January 2018

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All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

21 January 2018

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Merging molecular imaging and RNA interference: early experience in live animals

21 January 2018

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Size-dependent DNA mobility in cytoplasm and nucleus

21 January 2018

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Activation of the mammalian immune system by siRNAs.

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

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Global gene expression profiling in cultured cells is strongly influenced by treatment with siRNA-cationic liposome complexes

21 January 2018

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Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.

21 January 2018

1 reference

A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery

21 January 2018

1 reference

Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library

21 January 2018

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