Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids (Q57753953)

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Timur Rusanov

2

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Labiba A Siddique

4

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Richard T Pomerantz

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

6 April 2018

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published in

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volume

293

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issue

14

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page(s)

5259-5269

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cites work

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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.

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Dual loss of human POLQ and LIG4 abolishes random integration

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T-DNA integration in plants results from polymerase-θ-mediated DNA repair.

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Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

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Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.

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RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins

2 November 2018

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Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

2 November 2018

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Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes.

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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

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Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

2 November 2018

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Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

2 November 2018

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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ

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A role for DNA polymerase θ in the timing of DNA replication.

2 November 2018

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A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

2 November 2018

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Human RecQ helicases in DNA repair, recombination, and replication.

2 November 2018

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A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

2 November 2018

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Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.

2 November 2018

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HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

2 November 2018

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R loops: from transcription byproducts to threats to genome stability

2 November 2018

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Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures

2 November 2018

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Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

2 November 2018

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Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila

2 November 2018

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SF1 and SF2 helicases: family matters

2 November 2018

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Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

2 November 2018

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Structure of the DNA Repair Helicase Hel308 Reveals DNA Binding and Autoinhibitory Domains

2 November 2018

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RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

2 November 2018

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Structural basis for DNA duplex separation by a superfamily-2 helicase

2 November 2018

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POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

2 November 2018

1 reference

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Uncoupling of leading- and lagging-strand DNA replication during lesion bypass in vivo

2 November 2018

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Unraveling hot spots in binding interfaces: progress and challenges

2 November 2018

1 reference

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A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308

2 November 2018

1 reference

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

2 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892577

Escherichia coli helicase II (uvrD) protein can completely unwind fully duplex linear and nicked circular DNA.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5892577

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase

2 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29444826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Good and Bad of RNA:DNA Hybrids in Double-Strand Break Repair

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PubMed

https://pubmed.ncbi.nlm.nih.gov/29444826