Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? (Q28083182)

Crossref

author name string

Lorraine S. Symington

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

November 2015

1 reference

Trends in Biochemical Sciences

published in

1 reference

volume

40

1 reference

issue

11

1 reference

page(s)

701-14

1 reference

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

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Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection

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DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

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20 March 2017

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Structure of a NHEJ polymerase-mediated DNA synaptic complex

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Paired-end mapping reveals extensive structural variation in the human genome

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

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POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

20 March 2017

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Biochemical evidence for Ku-independent backup pathways of NHEJ

20 March 2017

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DNA end-joining catalyzed by human cell-free extracts

20 March 2017

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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

20 March 2017

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Factors determining DNA double-strand break repair pathway choice in G2 phase

20 March 2017

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Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

20 March 2017

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IgH class switching and translocations use a robust non-classical end-joining pathway

20 March 2017

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DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse

20 March 2017

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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

20 March 2017

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

20 March 2017

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Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

20 March 2017

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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ

20 March 2017

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Role of mammalian Mre11 in classical and alternative nonhomologous end joining

20 March 2017

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Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

20 March 2017

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Double-strand break end resection and repair pathway choice

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

7 April 2017

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Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis

7 April 2017

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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

29 September 2017

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Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

29 September 2017

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Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

29 September 2017

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Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.

29 September 2017

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RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

29 September 2017

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End-joining, translocations and cancer

29 September 2017

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RPA coordinates DNA end resection and prevents formation of DNA hairpins

29 September 2017

1 reference

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Repair of double-strand breaks by end joining

29 September 2017

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Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

29 September 2017

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PARP1 is required for chromosomal translocations.

29 September 2017

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Microhomology directs diverse DNA break repair pathways and chromosomal translocations

29 September 2017

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Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks

29 September 2017

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Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias

29 September 2017

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Removal of shelterin reveals the telomere end-protection problem

29 September 2017

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Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

29 September 2017

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CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

29 September 2017

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An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

29 September 2017

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Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

29 September 2017

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Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila

29 September 2017

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Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

29 September 2017

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An end-joining repair mechanism in Escherichia coli

29 September 2017

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Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements.

29 September 2017

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Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

29 September 2017

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Multiple roles for MRE11 at uncapped telomeres

29 September 2017

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Chromosomal translocations induced at specified loci in human stem cells.

29 September 2017

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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

29 September 2017

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Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

29 September 2017

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The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends

29 September 2017

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

29 September 2017

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Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2.

29 September 2017

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Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining

29 September 2017

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Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination

29 September 2017

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Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres

29 September 2017

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DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

29 September 2017

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Rejoining of DNA double-strand breaks as a function of overhang length

29 September 2017

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The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle

29 September 2017

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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

29 September 2017

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Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

29 September 2017

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Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining

29 September 2017

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Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences

29 September 2017

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Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae.

29 September 2017

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Double-strand break repair in Ku86- and XRCC4-deficient cells

29 September 2017

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The joining of non-complementary DNA double-strand breaks by mammalian extracts

29 September 2017

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Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

29 September 2017

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

29 September 2017

1 reference

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In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases.

29 September 2017

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REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination

29 September 2017

1 reference

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The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.

2 June 2018

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Microhomology-mediated intron loss during metazoan evolution.

2 June 2018

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The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

2 June 2018

1 reference

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Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation

2 June 2018

1 reference

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The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

2 June 2018

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Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining

2 June 2018

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Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease

2 June 2018

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A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

2 June 2018

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The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.

27 November 2018

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Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis

27 November 2018

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A robust network of double-strand break repair pathways governs genome integrity during C. elegans development.

27 November 2018

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The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae

27 November 2018

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Rejoining of DNA double-strand breaks in vitro by single-strand annealing.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4638128

Escape from telomere-driven crisis is DNA ligase III dependent

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26439531

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rag mutations reveal robust alternative end joining

1 reference

https://pubmed.ncbi.nlm.nih.gov/26439531