Intramuscular administration of a VEGF zinc finger transcription factor activator (VEGF-ZFP-TF) improves functional outcomes in SOD1 rats (Q58278823)

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11 February 2020

title

Intramuscular administration of a VEGF zinc finger transcription factor activator (VEGF-ZFP-TF) improves functional outcomes in SOD1 rats (English)

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11 February 2020

3

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author name string

Igor Radovitskiy

4

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11 February 2020

Bethwel Raore

5

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Emily Barrow

6

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11 February 2020

Thais Federici

8

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Michele A Kliem

1

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11 February 2020

Brenten L Heeke

2

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11 February 2020

Brooke R Snyder

7

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S Kaye Spratt

9

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Nicholas M Boulis

10

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publication date

24 August 2011

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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

11 February 2020

published in

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11 February 2020

volume

12

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issue

5

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page(s)

331-339

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Gene-based treatment of motor neuron diseases

11 February 2020

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VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

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Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS

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VEGF protects motor neurons against excitotoxicity by upregulation of GluR2.

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Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis

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AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice

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Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

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Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration

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Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice

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Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

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VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

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Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

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Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

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Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.

21 January 2018

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An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia.

21 January 2018

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Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

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Engineered zinc finger protein-mediated VEGF-a activation restores deficient VEGF-a in sensory neurons in experimental diabetes

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An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury

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10.3109/17482968.2011.574142

21 January 2018

Identifiers

DOI

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11 February 2020

1 reference