Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons (Q64119879)

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20 April 2020

title

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons (English)

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Huib Ovaa

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author name string

Vanessa F Langness

2

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Cheryl M Herrera

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Daniel A Williams

4

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20 April 2020

Lauren K Fong

5

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Yves Leestemaker

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Evelyne Steenvoorden

7

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Kevin D Rynearson

8

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Jos F Brouwers

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J Bernd Helms

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Martin Giera

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Steven L Wagner

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Anne G Bang

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Lawrence S B Goldstein

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language of work or name

English

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publication date

24 January 2019

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20 April 2020

volume

24

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20 April 2020

issue

3

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20 April 2020

page(s)

363-375.e9

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ImageJ

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11 June 2022

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cites work

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

12 December 2020

Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.

1 reference

12 December 2020

Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets

1 reference

12 December 2020

The interrelationship between selective tau phosphorylation and microtubule association

1 reference

12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

12 December 2020

Impaired proteasome function in Alzheimer's disease

1 reference

12 December 2020

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

12 December 2020

CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects

1 reference

12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

12 December 2020

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: the cholesterol connection

1 reference

12 December 2020

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

1 reference

12 December 2020

Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid.

1 reference

12 December 2020

Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway

1 reference

12 December 2020

Profiling proteasome activity in tissue with fluorescent probes

1 reference

12 December 2020

Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease.

1 reference

12 December 2020

Cellular cholesterol trafficking and compartmentalization

1 reference

12 December 2020

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

1 reference

12 December 2020

Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy

1 reference

12 December 2020

Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture

1 reference

12 December 2020

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

1 reference

12 December 2020

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

1 reference

12 December 2020

Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease

1 reference

12 December 2020

Lipids in Alzheimer's disease: A century-old story

1 reference

12 December 2020

The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.

1 reference

12 December 2020

What is a relevant statin concentration in cell experiments claiming pleiotropic effects?

1 reference

12 December 2020

Somatic coding mutations in human induced pluripotent stem cells

1 reference

12 December 2020

Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells

1 reference

12 December 2020

Linking lipids to Alzheimer's disease: cholesterol and beyond

1 reference

12 December 2020

A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome

1 reference

12 December 2020

Cholesterol metabolism in Huntington disease

1 reference

12 December 2020

Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies

1 reference

12 December 2020

Fluorescence-based proteasome activity profiling.

1 reference

12 December 2020

Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations

1 reference

12 December 2020

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

1 reference

12 December 2020

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

1 reference

12 December 2020

A human stem cell model of early Alzheimer's disease pathology in Down syndrome

1 reference

12 December 2020

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

1 reference

12 December 2020

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

1 reference

12 December 2020

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system

1 reference

12 December 2020

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease

1 reference

12 December 2020

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

1 reference

12 December 2020

The UPS and downs of cholesterol homeostasis.

1 reference

12 December 2020

Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions

1 reference

12 December 2020

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

1 reference

12 December 2020

A three-dimensional human neural cell culture model of Alzheimer's disease

1 reference

12 December 2020

Direct cellular delivery of human proteasomes to delay tau aggregation

1 reference

12 December 2020

Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells

1 reference

12 December 2020

APP metabolism regulates tau proteostasis in human cerebral cortex neurons

1 reference

12 December 2020

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

1 reference

12 December 2020

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.

1 reference

12 December 2020

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease.

1 reference

12 December 2020

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

1 reference

12 December 2020

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.

1 reference

12 December 2020

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

1 reference

12 December 2020

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

1 reference

12 December 2020

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond.

1 reference

12 December 2020

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.

1 reference

12 December 2020

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

1 reference

12 December 2020

Induced pluripotent stem cell technology: a decade of progress

1 reference

12 December 2020

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease

1 reference

12 December 2020

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

1 reference

12 December 2020

Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography-mass spectrometry.

1 reference

12 December 2020

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.

1 reference

12 December 2020

Proteasome Activation by Small Molecules.

1 reference

12 December 2020

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

1 reference

12 December 2020

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease.

1 reference

12 December 2020

Efavirenz: What is known about the cellular mechanisms responsible for its adverse effects

1 reference

12 December 2020

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease.

1 reference

12 December 2020

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.

1 reference

12 December 2020

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

1 reference

12 December 2020

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.

1 reference

12 December 2020

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes

1 reference

12 December 2020

10.1016/J.STEM.2018.12.013

Identifiers

DOI

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20 April 2020

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20 April 2020

PubMed publication ID

30686764

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