Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity (Q64236635)

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25 April 2020

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1 August 2020

24 January 2021

24 June 2021

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity (English)

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main subject

clinical trial

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adoptive immunotherapy

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transplantation tolerance

1 August 2020

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24 January 2021

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24 June 2021

1

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author name string

Giorgia Fanelli

2

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25 April 2020

Caraugh Jane Albany

3

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Giulio Giganti

4

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Giovanna Lombardi

5

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language of work or name

English

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publication date

31 January 2019

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1 August 2020

24 January 2021

24 June 2021

Frontiers in Immunology

4 references

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1 August 2020

24 January 2021

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page(s)

43

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Creative Commons Attribution 4.0 International

25 April 2020

copyright license

3 references

1 August 2020

24 January 2021

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

24 June 2021

cites work

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

Cloning and characterization of the thyroid iodide transporter

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12 December 2020

Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis

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12 December 2020

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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12 December 2020

Tolerogenic dendritic cells

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12 December 2020

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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12 December 2020

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

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12 December 2020

Role of LAG-3 in regulatory T cells.

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12 December 2020

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

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12 December 2020

T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.

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12 December 2020

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

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12 December 2020

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner

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12 December 2020

Inducing and expanding regulatory T cell populations by foreign antigen

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12 December 2020

Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells

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12 December 2020

Molecular mechanisms underlying FOXP3 induction in human T cells

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12 December 2020

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

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12 December 2020

Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients

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12 December 2020

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

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12 December 2020

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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12 December 2020

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

1 reference

12 December 2020

CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages.

1 reference

12 December 2020

Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target

1 reference

12 December 2020

Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg.

1 reference

12 December 2020

DNA methylation controls Foxp3 gene expression

1 reference

12 December 2020

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

1 reference

12 December 2020

Regulatory T cells and immune tolerance

1 reference

12 December 2020

How regulatory T cells work

1 reference

12 December 2020

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

1 reference

12 December 2020

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

1 reference

12 December 2020

Pathways of major histocompatibility complex allorecognition.

1 reference

12 December 2020

Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?

1 reference

12 December 2020

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

1 reference

12 December 2020

Abatacept in the treatment of rheumatoid arthritis

1 reference

12 December 2020

Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets.

1 reference

12 December 2020

Immunoregulatory functions of mTOR inhibition.

1 reference

12 December 2020

Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

1 reference

12 December 2020

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells

1 reference

12 December 2020

Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus

1 reference

12 December 2020

Extracellular redox modulation by regulatory T cells

1 reference

12 December 2020

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.

1 reference

12 December 2020

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

1 reference

12 December 2020

Novel role of regulatory T cells in limiting early neutrophil responses in skin

1 reference

12 December 2020

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

1 reference

12 December 2020

Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells

1 reference

12 December 2020

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

1 reference

12 December 2020

IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer.

1 reference

12 December 2020

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

1 reference

12 December 2020

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

1 reference

12 December 2020

Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

1 reference

12 December 2020

Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin

1 reference

12 December 2020

Regulatory T cells in stem cell transplantation: strategies and first clinical experiences.

1 reference

12 December 2020

In vivo SPECT reporter gene imaging of regulatory T cells.

1 reference

12 December 2020

Organ transplantation: historical perspective and current practice.

1 reference

12 December 2020

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

1 reference

12 December 2020

Molecular mechanisms of treg-mediated T cell suppression

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12 December 2020

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

1 reference

12 December 2020

Neutrophil--CD4+CD25+ T regulatory cell interactions: a possible new mechanism of infectious tolerance

1 reference

12 December 2020

T regulatory cell separation for clinical application.

1 reference

12 December 2020

Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

1 reference

12 December 2020

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations

1 reference

12 December 2020

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

1 reference

12 December 2020

Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.

1 reference

12 December 2020

Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy

1 reference

12 December 2020

Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease

1 reference

12 December 2020

The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer

1 reference

12 December 2020

The role of dendritic cells in autoimmunity

1 reference

12 December 2020

Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

1 reference

12 December 2020

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

1 reference

12 December 2020

Role of neutrophils in systemic autoimmune diseases

1 reference

12 December 2020

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

1 reference

12 December 2020

Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2rγnull mice

1 reference

12 December 2020

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

1 reference

12 December 2020

Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up

1 reference

12 December 2020

Once a Treg, always a Treg?

1 reference

12 December 2020

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus

1 reference

12 December 2020

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse.

1 reference

12 December 2020

Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells

1 reference

12 December 2020

Targeting Th17 cells in autoimmune diseases

1 reference

12 December 2020

Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions

1 reference

12 December 2020

Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand

1 reference

12 December 2020

Anti-TNF therapy: past, present and future

1 reference

12 December 2020

The brave new world of innate lymphoid cells

1 reference

12 December 2020

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis.

1 reference

12 December 2020

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

1 reference

12 December 2020

The need for minimization strategies: current problems of immunosuppression.

1 reference

12 December 2020

20-year survival post-liver transplant: much more is needed!

1 reference

12 December 2020

Regulatory T-Cell Development in the Human Thymus

1 reference

12 December 2020

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

1 reference

12 December 2020

Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells

1 reference

12 December 2020

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

1 reference

12 December 2020

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation.

1 reference

12 December 2020

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

1 reference

12 December 2020

Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation.

1 reference

12 December 2020

Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate

1 reference

12 December 2020

Genetic Factors of Autoimmune Diseases

1 reference

12 December 2020

Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells

1 reference

12 December 2020

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

1 reference

12 December 2020

AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease

1 reference

12 December 2020

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction

1 reference

12 December 2020

Neutrophil Dysfunction in Sepsis

1 reference

12 December 2020

Treg therapy in transplantation: a general overview.

1 reference

12 December 2020

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

1 reference

12 December 2020

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

1 reference

12 December 2020

The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications

1 reference

12 December 2020

Regulatory T cells: tolerance induction in solid organ transplantation

1 reference

12 December 2020

Clinical Evidence for the Microbiome in Inflammatory Diseases

1 reference

12 December 2020

Novel treatment strategies in rheumatoid arthritis.

1 reference

12 December 2020

TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation

1 reference

12 December 2020

Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.

1 reference

12 December 2020

Antigen-specific regulatory T cells: are police CARs the answer?

1 reference

12 December 2020

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment.

1 reference

12 December 2020

The development of T cells from stem cells in mice and humans

1 reference

12 December 2020

TNFR2: A Novel Target for Cancer Immunotherapy

1 reference

12 December 2020

Engineered T Regulatory Type 1 Cells for Clinical Application.

1 reference

12 December 2020

Approved CAR T cell therapies: ice bucket challenges on glaring safety risks and long-term impacts

1 reference

12 December 2020

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials.

1 reference

12 December 2020

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants.

1 reference

12 December 2020

Regulatory T cells induce activation rather than suppression of human basophils

1 reference

12 December 2020

Regulatory T cells in autoimmune disease

1 reference

12 December 2020

CAR T cells for infection, autoimmunity and allotransplantation

1 reference

12 December 2020

Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells

1 reference

12 December 2020

Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus

1 reference

12 December 2020

Cell surface polysaccharides of induce the generation of Foxp3 regulatory T cells

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2019.00043

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30804926%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30804926%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

PubMed publication ID

30804926

1 reference