Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding (Q73107054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10531318%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding (English)

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1 November 2019

author name string

R P Nagarajan

series ordinal

1

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1 November 2019

J Liu

series ordinal

2

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1 November 2019

Y Chen

series ordinal

3

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1 November 2019

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

1 November 2019

published in

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1 November 2019

volume

274

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1 November 2019

issue

44

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1 November 2019

page(s)

31229-31235

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TGF-beta signal transduction

1 November 2019

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

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Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts

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A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins

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Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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Smad6 inhibits signalling by the TGF-beta superfamily

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Daughters against dpp modulates dpp organizing activity in Drosophila wing development

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Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos

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SMADs: mediators and regulators of TGF-beta signaling

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Smads: transcriptional activators of TGF-beta responses

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A transcriptional partner for MAD proteins in TGF-beta signalling

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Smad4 and FAST-1 in the assembly of activin-responsive factor

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Characterization of human FAST-1, a TGF beta and activin signal transducer

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Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

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FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

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Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

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Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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Human Smad3 and Smad4 are sequence-specific transcription activators

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.44.31229

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10531318%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference