Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: version 3 (Q74669209)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10102034%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: version 3 (English)

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12 November 2019

2

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12 November 2019

author name string

E C Friedberg

series ordinal

1

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12 November 2019

language of work or name

English

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publication date

1 March 1999

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12 November 2019

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12 November 2019

volume

433

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12 November 2019

issue

2

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12 November 2019

page(s)

69-87

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Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 2

12 November 2019

cites work

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

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The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

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A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.

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DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability

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Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

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Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

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7 January 2021

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

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7 January 2021

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

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7 January 2021

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

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7 January 2021

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

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7 January 2021

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

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7 January 2021

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC

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7 January 2021

Characterization of defective nucleotide excision repair in XPC mutant mice

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Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer.

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Genetic interaction between HAP1/REF-1 and p53

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7 January 2021

A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy

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7 January 2021

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

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7 January 2021

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

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7 January 2021

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

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7 January 2021

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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7 January 2021

MSH2 deficient mice are viable and susceptible to lymphoid tumours

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7 January 2021

Female embryonic lethality in mice nullizygous for both Msh2 and p53

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7 January 2021

No female embryonic lethality in mice nullizygous for Msh2 and p53

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7 January 2021

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

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7 January 2021

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

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7 January 2021

Meiotic pachytene arrest in MLH1-deficient mice

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7 January 2021

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

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7 January 2021

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

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7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

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7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

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7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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7 January 2021

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

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7 January 2021

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

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7 January 2021

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

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7 January 2021

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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7 January 2021

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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7 January 2021

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

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7 January 2021

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

1 reference

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7 January 2021

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

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7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

1 reference

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7 January 2021

Brca2 is required for embryonic cellular proliferation in the mouse

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7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

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7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

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7 January 2021

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2898%2900068-8

7 January 2021

10.1016/S0921-8777(98)00068-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10102034%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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