Methods for screening drugs for their pro-arrhythmic liability: does the rabbit ventricular wedge hold the key? (Q79745683)

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25 December 2019

title

Methods for screening drugs for their pro-arrhythmic liability: does the rabbit ventricular wedge hold the key? (English)

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25 December 2019

author name string

Jules C Hancox

series ordinal

1

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25 December 2019

Michael J Curtis

series ordinal

2

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25 December 2019

publication date

27 April 2006

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Journal of Pharmacological and Toxicological Methods

25 December 2019

published in

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25 December 2019

volume

54

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25 December 2019

issue

3

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25 December 2019

page(s)

257-260

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Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

25 December 2019

cites work

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Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome

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Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

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Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models

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Assessment of drug-induced QT interval prolongation in conscious rabbits

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Mechanisms underlying arrhythmogenesis in long QT syndrome

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Nonclinical proarrhythmia models: predicting Torsades de Pointes

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.

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Structural determinants and biophysical properties of HERG and KCNQ1 channel gating

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7 January 2021

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HERG K+ channels: friend and foe.

7 January 2021

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Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

7 January 2021

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Cellular basis for the electrocardiographic J wave

7 January 2021

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Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome

7 January 2021

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Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

7 January 2021

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Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall

7 January 2021

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10.1016/J.VASCN.2006.04.003

7 January 2021

Identifiers

DOI

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25 December 2019

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