Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation (Q80163724)

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scientific article published on 08 December 2007

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English	Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation	scientific article published on 08 December 2007

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scholarly article

1 reference

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29 December 2019

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation (English)

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29 December 2019

Antonello Pileggi

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29 December 2019

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29 December 2019

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29 December 2019

Camillo Ricordi

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29 December 2019

Adrián González-Quintana

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J Gonzalez-Quintana

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29 December 2019

author name string

A Fornoni

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29 December 2019

N Y Sanabria

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29 December 2019

T Tejada

5

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29 December 2019

L Inverardi

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29 December 2019

R L Pastori

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29 December 2019

publication date

8 December 2007

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29 December 2019

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29 December 2019

51

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29 December 2019

298-308

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29 December 2019

2

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29 December 2019

https://scigraph.springernature.com/pub.10.1007/s00125-007-0889-4

0 references

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

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Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

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12 December 2020

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Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets

1 reference

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Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor

1 reference

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12 December 2020

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Improved functional survival of human islets of Langerhans in three-dimensional matrix culture

1 reference

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12 December 2020

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Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta.

1 reference

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Structural and functional changes resulting from islet isolation lead to islet cell death.

1 reference

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12 December 2020

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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

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12 December 2020

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Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy.

1 reference

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12 December 2020

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The l-isoform but not d-isoforms of a JNK inhibitory peptide protects pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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A central role for JNK in obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Insulin feedback action on pancreatic beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Technical aspects of islet preparation and transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.

1 reference

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12 December 2020

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Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Islet isolation assessment in man and large animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Activation of Macrophage-Associated Molecules after Brain Death in Islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Autocrine insulin action activates Akt and increases survival of isolated human islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Phosphatidylinositol 3-kinase signaling to Akt mediates survival in isolated canine islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Identification and purification of functional human beta-cells by a new specific zinc-fluorescent probe

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

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Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

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Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

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Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Nitric oxide and mitochondrial complex IV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

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A simple method of staining fresh and cultured islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

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Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

1 reference

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Clinical islet transplantation: advances and immunological challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

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Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

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Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue purification maximizes the use of human islet preparations for transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein transduction technology: a novel therapeutic perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine-stimulated phosphorylation of GSK-3 is primarily dependent upon PKCs, not PKB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18066521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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