Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3 (Q80653943)

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2 January 2020

title

Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3 (English)

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ChEBI release 2020-05-28

Nam-Hoon Kim

1

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2 January 2020

Mun-Yong Lee

2

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2 January 2020

Seon-Joo Park

3

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2 January 2020

Jeong-Sun Choi

4

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Mi-Kyung Oh

5

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In-Sook Kim

6

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publication date

20 July 2007

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volume

122

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issue

4

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page(s)

607-614

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Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes

2 January 2020

cites work

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12 December 2020

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

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12 December 2020

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase

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12 December 2020

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12 December 2020

Soluble interleukin-6 receptor alpha inhibits the cytokine-Induced fractalkine/CX3CL1 expression in human vascular endothelial cells in culture

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12 December 2020

Constitutive activation of STAT transcription factors in acute myelogenous leukemia

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12 December 2020

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

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12 December 2020

Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit

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12 December 2020

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

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12 December 2020

Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis

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12 December 2020

Auranofin improves outcome in early rheumatoid arthritis. Results from a 2-year, double blind placebo controlled study

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12 December 2020

Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro

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12 December 2020

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

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12 December 2020

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

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12 December 2020

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

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12 December 2020

The acute phase response

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12 December 2020

Cytokine receptor signalling

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12 December 2020

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

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12 December 2020

Gp130 and the interleukin-6 family of cytokines

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12 December 2020

Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1.

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12 December 2020

Interleukin 6 and its receptor: ten years later

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12 December 2020

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds

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12 December 2020

Activation of the JAK-STAT pathway by reactive oxygen species.

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12 December 2020

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12 December 2020

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

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12 December 2020

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

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12 December 2020

The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells

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12 December 2020

Angiogenesis in rheumatoid arthritis

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12 December 2020

Interleukin-6 in rheumatoid arthritis

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12 December 2020

Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4.

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12 December 2020

The JAK-STAT signaling pathway: input and output integration

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12 December 2020

Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

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12 December 2020

10.1111/J.1365-2567.2007.02679.X

Identifiers

DOI

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