VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis (Q86509911)

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scientific article published on 01 January 2014

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English	VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis	scientific article published on 01 January 2014

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27 February 2020

VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis (English)

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27 February 2020

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I Mendel

1

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27 February 2020

E Feige

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27 February 2020

N Yacov

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27 February 2020

Y Salem

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27 February 2020

I Levi

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27 February 2020

O Propheta-Meiran

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27 February 2020

A Shoham

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27 February 2020

E Ishai

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27 February 2020

J George

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27 February 2020

D Harats

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27 February 2020

E Breitbart

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27 February 2020

publication date

1 January 2014

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27 February 2020

Clinical and Experimental Immunology

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27 February 2020

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27 February 2020

1

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27 February 2020

126-137

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27 February 2020

Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis: current pathogenesis and therapeutic options

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis and plasma and liver lipids in nine inbred strains of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oxidation hypothesis of atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma potentiates atherosclerosis in ApoE knock-out mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis — An Inflammatory Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of CD14 and its implications for lipopolysaccharide signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, atherosclerosis, and coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized Phospholipids Negatively Regulate Dendritic Cell Maturation Induced by TLRs and CD40

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of atherosclerosis in mice by Toll-like receptor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells in atherogenesis: for better or for worse?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immunity, macrophage activation, and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized phospholipids induce anergy in human peripheral blood T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherogenesis and the humoral immune response to modified lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune and inflammatory mechanisms of atherosclerosis (*)

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive immunity and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular toll-like receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24116867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/CEI.12212

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27 February 2020

PubMed publication ID

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PubMed publication ID

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27 February 2020

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