Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis (Q89222822)

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2 April 2020

title

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis (English)

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11

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10

Guido Kroemer

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12

Timothy R Billiar

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author name string

Rui Kang

1

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Ling Zeng

2

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Shan Zhu

3

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Yangchun Xie

4

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Jiao Liu

5

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Qirong Wen

6

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Lizhi Cao

7

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Min Xie

8

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Qitao Ran

9

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Jianxin Jiang

13

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Daolin Tang

14

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publication date

21 June 2018

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volume

24

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issue

1

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page(s)

97-108.e4

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Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g

2 April 2020

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

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12 December 2020

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

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12 December 2020

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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Converging roles of caspases in inflammasome activation, cell death and innate immunity

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12 December 2020

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

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Pore-forming activity and structural autoinhibition of the gasdermin family

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12 December 2020

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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12 December 2020

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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12 December 2020

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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Identification of ACSL4 as a biomarker and contributor of ferroptosis

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Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

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Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

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Programmed cell death as a defence against infection

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12 December 2020

Lipid peroxidation in cell death

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Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

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12 December 2020

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

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12 December 2020

Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

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12 December 2020

ALK is a therapeutic target for lethal sepsis.

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12 December 2020

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

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Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis.

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12 December 2020

10.1016/J.CHOM.2018.05.009

Identifiers

DOI

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2 April 2020

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2 April 2020

PubMed publication ID

29937272

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