The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc (Q24314734)

1

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Xiaoli Zhang

2

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Colin J Daniel

3

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Deanne Tibbitts

4

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Julie Escamilla-Powers

5

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Amy Farrell

6

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Sara Tokarz

7

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Charlie Morgan

8

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Rosalie C Sears

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

9

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language of work or name

English

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publication date

4 March 2009

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published in

The EMBO Journal

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volume

28

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issue

5

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page(s)

500-12

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cites work

1 reference

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The links between axin and carcinogenesis

19 March 2017

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

19 March 2017

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Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

19 March 2017

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The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

19 March 2017

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SSRP1 functions as a co-activator of the transcriptional activator p63

19 March 2017

1 reference

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Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

19 March 2017

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Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

19 March 2017

1 reference

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Identification of c-MYC as a target of the APC pathway

19 March 2017

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

19 March 2017

1 reference

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

19 March 2017

1 reference

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Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

19 March 2017

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Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

19 March 2017

1 reference

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Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

19 March 2017

1 reference

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Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

19 March 2017

1 reference

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Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

19 March 2017

1 reference

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Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

19 March 2017

1 reference

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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

19 March 2017

1 reference

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

19 March 2017

1 reference

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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

19 March 2017

1 reference

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

19 March 2017

1 reference

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The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

19 March 2017

1 reference

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

19 March 2017

1 reference

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Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

p14ARF directly interacts with Myc through the Myc BoxII domain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

The life cycle of C-myc: from synthesis to degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

p19ARF directly and differentially controls the functions of c-Myc independently of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

27 September 2017

1 reference

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Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Function of the c-Myc oncogenic transcription factor.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Ras enhances Myc protein stability.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2657573

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

27 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.279

Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.279

A conserved pathway that controls c-Myc protein stability through opposing phosphorylation events occurs in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.279

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.279

Axin and hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.279

Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.279

21 January 2018

Identifiers

DOI

10.1038/EMBOJ.2008.279

1 reference

4253277

4253277

1 reference

1 reference

1 reference