Sirtuin 1 (Q21498104)

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mammalian protein found in Mus musculus
  • Sirt1
  • SIR2-like protein 1
  • sirtuin 1 ((silent mating type information regulation 2, homolog) 1
  • regulatory protein SIR2 homolog 1
  • NAD-dependent protein deacetylase sirtuin-1
  • Sir2
  • mSIR2a
  • NAD-dependent protein deacylase sirtuin-1
  • SIR2alpha
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Language Label Description Also known as
English
Sirtuin 1
mammalian protein found in Mus musculus
  • Sirt1
  • SIR2-like protein 1
  • sirtuin 1 ((silent mating type information regulation 2, homolog) 1
  • regulatory protein SIR2 homolog 1
  • NAD-dependent protein deacetylase sirtuin-1
  • Sir2
  • mSIR2a
  • NAD-dependent protein deacylase sirtuin-1
  • SIR2alpha

Statements

molecular function
protein deacetylase activity
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
9 May 2019
stated in
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
ISO
retrieved
9 May 2019
stated in
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IMP
retrieved
9 May 2019
stated in
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IMP
retrieved
9 May 2019
stated in
Metastasis-associated protein 1 is an integral component of the circadian molecular machinery
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IEA
retrieved
9 May 2019
stated in
Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA
protein binding
determination method
IPI
25 references
retrieved
9 May 2019
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
retrieved
9 May 2019
stated in
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
ISO
8 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IEA
retrieved
9 May 2019
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA
retrieved
9 May 2019
stated in
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA
retrieved
9 May 2019
stated in
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA
retrieved
9 May 2019
stated in
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA
retrieved
9 May 2019
stated in
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA
biological process
protein deacetylation
determination method
IDA
IEA
IMP
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
ISO
retrieved
9 May 2019
stated in
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IMP
retrieved
9 May 2019
stated in
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
GOA
curator
UniProt
UniProt protein ID
Q923E4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IMP
retrieved
9 May 2019
stated in
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IEA
retrieved
9 May 2019
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4
determination method
IDA

Identifiers

 
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