Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses (Q24293580)

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

Sirtuin 1

1 reference

Hypermethylated in cancer 1

1 reference

6

Stephen B Baylin

0 references

author name string

Wen Yong Chen

1

0 references

David H Wang

2

0 references

Raywhay Chiu Yen

3

0 references

Jianyuan Luo

4

0 references

Wei Gu

A genetic model for colorectal tumorigenesis

5

0 references

language of work or name

English

0 references

publication date

4 November 2005

0 references

published in

Cell

0 references

volume

123

0 references

issue

3

0 references

page(s)

437-48

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Mammalian SIRT1 represses forkhead transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

The fundamental role of epigenetic events in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Histone deacetylases (HDACs): characterization of the classical HDAC family

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

CpG island methylator phenotype in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

The POZ domain: a conserved protein-protein interaction motif

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021

Sirtuins: Sir2-related NAD-dependent protein deacetylases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.08.011

7 January 2021