TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 (Q24293153)

activation of GTPase activity

GOA release 2020-03-11

1 reference

TBC1 domain family, member 7

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

6

John M Asara

John M

Asara

1 reference

19 October 2023

Christian C Dibble

1

Christian C

Dibble

1 reference

19 October 2023

Winfried Elis

2

Winfried

Elis

1 reference

19 October 2023

Suchithra Menon

3

Suchithra

Menon

1 reference

19 October 2023

Wei Qin

4

Wei

Qin

1 reference

19 October 2023

Justin Klekota

5

Justin

Klekota

1 reference

19 October 2023

Peter M Finan

7

Peter M

Finan

1 reference

19 October 2023

David J Kwiatkowski

8

David J

Kwiatkowski

1 reference

19 October 2023

Leon O Murphy

9

Leon O

Murphy

1 reference

19 October 2023

Brendan D Manning

10

Brendan D

describes a project that uses

Manning

1 reference

19 October 2023

language of work or name

English

0 references

publication date

24 August 2012

0 references

published in

Molecular Cell

0 references

volume

47

0 references

page(s)

535-46

0 references

issue

4

0 references

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3693578/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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1 reference

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

19 March 2017

1 reference

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A complex interplay between Akt, TSC2 and the two mTOR complexes

19 March 2017

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

19 March 2017

1 reference

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

19 March 2017

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

19 March 2017

1 reference

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Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex

19 March 2017

1 reference

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Functional dissection of Rab GTPases involved in primary cilium formation

19 March 2017

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

19 March 2017

1 reference

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The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

19 March 2017

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

19 March 2017

1 reference

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

19 March 2017

1 reference

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Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

19 March 2017

1 reference

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Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

19 March 2017

1 reference

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

19 March 2017

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

19 March 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

19 March 2017

1 reference

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The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

19 March 2017

1 reference

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

19 March 2017

1 reference

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The LKB1 tumor suppressor negatively regulates mTOR signaling

19 March 2017

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

19 March 2017

1 reference

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

19 March 2017

1 reference

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

19 March 2017

1 reference

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

19 March 2017

1 reference

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

19 March 2017

1 reference

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19 March 2017

1 reference

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

19 March 2017

1 reference

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Regulation of TORC1 by Rag GTPases in nutrient response

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1 reference

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1 reference

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Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 April 2017

1 reference

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Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.

7 April 2017

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27 September 2017

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Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

27 September 2017

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27 September 2017

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Tandem affinity purification and identification of the human TSC1 protein complex.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Ultra deep sequencing detects a low rate of mosaic mutations in tuberous sclerosis complex

27 September 2017

1 reference

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Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Common corruption of the mTOR signaling network in human tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Distinct clinical characteristics of tuberous sclerosis complex patients with no mutation identified

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Evolution of the TSC1/TSC2-TOR signaling pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3693578

TSC1, TSC2, TSC3? Or mosaicism?

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22795129

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2012.06.009

1 reference

release_kfitjeuogrf3bb67w3tcw7kvzq

1647229

Fatcat ID

0 references

1647229

1 reference

1 reference

1 reference