Argonaute RISC catalytic component 2 (Q21115073)

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mammalian protein found in Homo sapiens
  • eIF-2C 2
  • eIF2C 2
  • eukaryotic translation initiation factor 2C, 2
  • AGO2
  • protein argonaute-2
  • cancer susceptibility candidate 7
  • argonaute RISC catalytic component 2
  • cancer susceptibility candidate 7 (non-protein coding)
  • PPD
  • Eukaryotic translation initiation factor 2C 2
  • protein slicer
  • argonaute 2, RISC catalytic component
  • PAZ Piwi domain protein
  • long intergenic non-protein coding RNA 980
edit
Language Label Description Also known as
English
Argonaute RISC catalytic component 2
mammalian protein found in Homo sapiens
  • eIF-2C 2
  • eIF2C 2
  • eukaryotic translation initiation factor 2C, 2
  • AGO2
  • protein argonaute-2
  • cancer susceptibility candidate 7
  • argonaute RISC catalytic component 2
  • cancer susceptibility candidate 7 (non-protein coding)
  • PPD
  • Eukaryotic translation initiation factor 2C 2
  • protein slicer
  • argonaute 2, RISC catalytic component
  • PAZ Piwi domain protein
  • long intergenic non-protein coding RNA 980

Statements

molecular function
protein binding
determination method
IPI
52 references
retrieved
8 April 2019
stated in
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Identification of novel argonaute-associated proteins
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
MicroRNA silencing through RISC recruitment of eIF6
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9)
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
RNA helicase A interacts with RISC in human cells and functions in RISC loading
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of microRNA in AU-rich element-mediated mRNA instability
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Post-transcriptional gene silencing activity of human GIGYF2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
eIF4GI facilitates the MicroRNA-mediated gene silencing
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of telomerase reverse transcriptase in heterochromatin maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Defining a new role of GW182 in maintaining miRNA stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
The role of PACT in the RNA silencing pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
In vitro reconstitution of the human RISC-loading complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into RNA processing by the human RISC-loading complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Identification of potential protein interactors of Lrrk2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Structural features of Argonaute-GW182 protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian microtubule P-body dynamics are mediated by nesprin-1.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
cell component
RISC-loading complex
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
8 April 2019
stated in
RNA helicase A interacts with RISC in human cells and functions in RISC loading
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
Structural insights into RNA processing by the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
In vitro reconstitution of the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
ATP-dependent human RISC assembly pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
RISC complex
determination method
IC
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
1 January 2018
stated in
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
1 January 2018
stated in
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
1 January 2018
stated in
ATP-dependent human RISC assembly pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
1 January 2018
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IC
RISC complex
determination method
IC
IDA
IEA
IPI
8 references
retrieved
8 April 2019
stated in
An integrated approach for experimental target identification of hypoxia-induced miR-210
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UKV8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IEA
retrieved
8 April 2019
stated in
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
ATP-dependent human RISC assembly pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IDA
retrieved
8 April 2019
stated in
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV8
determination method
IC
biological process

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115073&oldid=2022960629"