The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways (Q24302411)

Gene Ontology release 2020-05-02

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PGAM family member 5, mitochondrial serine/threonine protein phosphatase

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Receptor interacting serine/threonine kinase 3

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Mixed lineage kinase domain like pseudokinase

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Receptor interacting serine/threonine kinase 1

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Tumor necrosis factor

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positive regulation of necroptotic process

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Phosphoglycerate mutase family member 5

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Dynamin 1-like

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Receptor-interacting serine-threonine kinase 3

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1 reference

Hui Jiang

2

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Xiaodong Wang

object named as

Xiaodong Wang

5

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author name string

Zhigao Wang

1

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She Chen

3

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Fenghe Du

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

4

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language of work or name

English

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publication date

20 January 2012

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published in

Cell

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volume

148

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issue

1-2

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page(s)

228-43

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cites work

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7 January 2021

TNF-alpha induces two distinct caspase-8 activation pathways

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

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RIP kinases at the crossroads of cell death and survival

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

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7 January 2021

Virus inhibition of RIP3-dependent necrosis

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Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

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7 January 2021

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

1 reference

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7 January 2021

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

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https://api.crossref.org/works/10.1016%2FJ.CELL.2011.11.030

7 January 2021

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

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7 January 2021

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

1 reference

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7 January 2021

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

1 reference

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7 January 2021

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

1 reference

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7 January 2021

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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7 January 2021

Identification of RIP1 kinase as a specific cellular target of necrostatins

1 reference

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7 January 2021

The BCL-2 protein family: opposing activities that mediate cell death

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7 January 2021

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

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7 January 2021

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

1 reference

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7 January 2021

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

1 reference

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7 January 2021

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

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7 January 2021

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.

1 reference

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7 January 2021

Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis

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7 January 2021

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

1 reference

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7 January 2021

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Mammalian dynamin-like protein DLP1 tubulates membranes

1 reference

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7 January 2021

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

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7 January 2021

Molecular mechanisms and physiologic functions of mitochondrial dynamics

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7 January 2021

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

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Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis

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The role of mitochondria in apoptosis*.

1 reference

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The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

1 reference

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7 January 2021

Molecular mechanisms and pathophysiology of necrotic cell death

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7 January 2021

10.1016/J.CELL.2011.11.030

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

release_7rxiup62gnbd5exgejhlx4z4ly

249432

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/7rxiup62gnbd5exgejhlx4z4ly

24 November 2022

mapped directly with Wikidata item

249432

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference