Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation (Q24302554)

SMAD family member 7

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Forkhead box H1

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SMAD family member 2

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transforming growth factor beta 1

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DNA-binding transcription factor activity

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Anming Meng

9

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ORCID Public Data File 2021

Xin-Hua Feng

8

object named as

Xin-Hua Feng

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author name string

Suping Zhang

1

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Teng Fei

2

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Lixia Zhang

3

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Ran Zhang

4

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Feng Chen

5

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Yuanheng Ning

6

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Yuna Han

7

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Ye-Guang Chen

Molecular and Cellular Biology

10

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language of work or name

English

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publication date

June 2007

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published in

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volume

27

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issue

12

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page(s)

4488-99

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cites work

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GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter

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Smad transcription factors

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

19 March 2017

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TGFbeta signaling in growth control, cancer, and heritable disorders

19 March 2017

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Controlling TGF-beta signaling

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Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

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Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors

19 March 2017

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Smads and early developmental signaling by the TGFbeta superfamily

19 March 2017

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Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

19 March 2017

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

19 March 2017

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Smad4 and FAST-1 in the assembly of activin-responsive factor

19 March 2017

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19 March 2017

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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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Specificity and versatility in tgf-beta signaling through Smads

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Transcriptional control by the TGF-beta/Smad signaling system

7 April 2017

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

7 April 2017

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Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription

7 April 2017

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Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

27 September 2017

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Regulation of TGF-beta signaling and its roles in progression of tumors

27 September 2017

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Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

27 September 2017

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The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling

27 September 2017

1 reference

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A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling

27 September 2017

1 reference

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

27 September 2017

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The Smads: transcriptional regulation and mouse models

27 September 2017

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Characterization of a bone morphogenetic protein-responsive Smad-binding element

27 September 2017

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Regulation of Smad7 promoter by direct association with Smad3 and Smad4.

27 September 2017

1 reference

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Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways

27 September 2017

1 reference

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Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

27 September 2017

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Induction of Smad6 mRNA by bone morphogenetic proteins

27 September 2017

1 reference

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Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Mechanism of TGFbeta receptor inhibition by FKBP12

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Zebrafish Smad7 is regulated by Smad3 and BMP signals.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Smad6 inhibits signalling by the TGF-beta superfamily.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900056

Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17438144