Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1) (Q24307730)

Mitogen-activated protein kinase 12

Europe PubMed Central

title

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1) (English)

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main subject

biochemistry

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Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

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HtrA serine peptidase 2

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PTEN induced kinase 1

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Parkin RBR E3 ubiquitin protein ligase

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AKT serine/threonine kinase 1

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TNF receptor associated factor 2

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TNF receptor associated protein 1

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negative regulation of neuron death

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Heung-Chin Cheng

6

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Terrence D. Mulhern

object named as

Terrence D Mulhern

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author name string

Ryan D Mills

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Chou Hung Sim

2

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Su San Mok

3

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Janetta G Culvenor

Journal of Neurochemistry

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language of work or name

English

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publication date

April 2008

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published in

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volume

105

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issue

1

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page(s)

18-33

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cites work

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

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Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion

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Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

20 April 2017

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Synthesis and function of 3-phosphorylated inositol lipids

20 April 2017

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Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

20 April 2017

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

20 April 2017

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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The PINK1/Parkin pathway regulates mitochondrial morphology

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

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Adult neuron survival strategies--slamming on the brakes

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Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families

21 January 2018

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Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

21 January 2018

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Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis.

21 January 2018

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Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment

21 January 2018

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Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons

21 January 2018

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A tale of two mitochondrial channels, MAC and PTP, in apoptosis

21 January 2018

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Progress in the clinical and molecular genetics of familial parkinsonism

21 January 2018

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21 January 2018

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PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism.

21 January 2018

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Deciphering the role of heterozygous mutations in genes associated with parkinsonism

21 January 2018

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Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

21 January 2018

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Proline residues of transmembrane domains determine the sorting of inner membrane proteins in mitochondria

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin: a multifaceted ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Neurodegenerative disease: pink, parkin and the brain.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Inhibition of apoptotic signaling cascades causes loss of trophic factor dependence during neuronal maturation

21 January 2018

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NF-kappaB signaling: flipping the switch with polyubiquitin chains

21 January 2018

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Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

21 January 2018

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

21 January 2018

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

21 January 2018

1 reference

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C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

21 January 2018

1 reference

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21 January 2018

Parkin blushed by PINK1.

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Pathogenic mutations in Parkinson disease

21 January 2018

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Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain

21 January 2018

1 reference

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Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Apoptosis in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Cleavage-site motifs in mitochondrial targeting peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

A heterozygous effect for PINK1 mutations in Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

Heterozygous PINK1 mutations: a susceptibility factor for Parkinson disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Phenotypic spectrum of PINK1-associated parkinsonism in 15 mutation carriers from 1 family

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

The mitochondrial machinery for import of precursor proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Protein import into mitochondria: two systems acting in tandem?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Protein insertion into the inner membrane of mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Analysis of PINK1 in Asian patients with familial parkinsonism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021

Programmed cell death and new discoveries in the genetics of parkinsonism.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05249.X

7 January 2021