Programmed cell death and new discoveries in the genetics of parkinsonism. (Q34859364)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17996022%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

1 reference

title

Programmed cell death and new discoveries in the genetics of parkinsonism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17996022%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17996022%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

author name string

Robert E Burke

series ordinal

1

1 reference

PubMed ID

17996022

4 August 2017

language of work or name

English

0 references

publication date

10 December 2007

1 reference

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Journal of Neurochemistry

10 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17996022%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

104

1 reference

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10 January 2020

issue

4

1 reference

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10 January 2020

page(s)

875-890

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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

10 January 2020

cites work

1 reference

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

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Signal integration in the endoplasmic reticulum unfolded protein response

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

8 July 2018

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Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

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Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

8 July 2018

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Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation

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DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

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8 July 2018

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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

8 July 2018

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

8 July 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

8 July 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

8 July 2018

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Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

8 July 2018

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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

8 July 2018

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

8 July 2018

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CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

8 July 2018

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

8 July 2018

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Molecular pathophysiology of Parkinson's disease

8 July 2018

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Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

8 July 2018

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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

8 July 2018

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

8 July 2018

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The biochemistry of Parkinson's disease

8 July 2018

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Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells

8 July 2018

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

8 July 2018

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Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice

8 July 2018

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The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

8 July 2018

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8 July 2018

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8 July 2018

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

8 July 2018

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Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.

8 July 2018

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8 July 2018

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8 July 2018

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

8 July 2018

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8 July 2018

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Molecular mechanisms of caspase regulation during apoptosis

8 July 2018

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

8 July 2018

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Caspases involved in ER stress-mediated cell death

8 July 2018

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PI 3-kinase, Akt and cell survival

8 July 2018

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

8 July 2018

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The neuromythology of Parkinson's Disease

8 July 2018

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Akt as a mediator of cell death

8 July 2018

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Akt2 Negatively Regulates Assembly of the POSH-MLK-JNK Signaling Complex

8 July 2018

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

8 July 2018

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Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

8 July 2018

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The death effector domain protein family: regulators of cellular homeostasis

8 July 2018

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Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation

8 July 2018

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Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

8 July 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

8 July 2018

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

8 July 2018

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Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons

8 July 2018

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

8 July 2018

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

8 July 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

8 July 2018

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Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

8 July 2018

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Akt1 regulates a JNK scaffold during excitotoxic apoptosis

8 July 2018

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JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery

8 July 2018

1 reference

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

8 July 2018

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

8 July 2018

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Human caspase 12 has acquired deleterious mutations

8 July 2018

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Mechanisms of caspase activation and inhibition during apoptosis

8 July 2018

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DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

8 July 2018

1 reference

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

8 July 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

8 July 2018

1 reference

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Ten years of protein kinase B signalling: a hard Akt to follow

8 July 2018

1 reference

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

8 July 2018

1 reference

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

8 July 2018

1 reference

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Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

8 July 2018

1 reference

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Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

8 July 2018

1 reference

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

8 July 2018

1 reference

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

8 July 2018

1 reference

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The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

8 July 2018

1 reference

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

8 July 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

The TNF and TNF receptor superfamilies: integrating mammalian biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Akt regulates cell survival and apoptosis at a postmitochondrial level

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

TOR, a central controller of cell growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Neurotrophin signal transduction in the nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Tripartite management of unfolded proteins in the endoplasmic reticulum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Cellular survival: a play in three Akts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Molecular characterization of mitochondrial apoptosis-inducing factor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

The Bcl-2 protein family: arbiters of cell survival

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

8 July 2018

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Daxx, a novel Fas-binding protein that activates JNK and apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Regulation of neuronal survival by the serine-threonine protein kinase Akt

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Regulation of Akt/PKB Ser473 phosphorylation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Cancer: survival pathways meet their end.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Autosomal recessive juvenile parkinsonism Cys212Tyr mutation in parkin renders lymphocytes susceptible to dopamine- and iron-mediated apoptosis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082499

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17996022

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17996022

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1471-4159.2007.05106.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17996022%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17996022%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference