Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway (Q24311625)

5

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author name string

Katharina Uhlenbrock

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Matthias Weiwad

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Reinhard Wetzker

3

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Gunter Fischer

4

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Ignacio Rubio

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

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language of work or name

English

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publication date

18 March 2009

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published in

FEBS Letters

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volume

583

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issue

6

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page(s)

965-70

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cites work

1 reference

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mTOR, translation initiation and cancer

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mTOR and cancer: insights into a complex relationship

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

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Regulation of the small GTPase Rheb by amino acids.

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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Rheb binds and regulates the mTOR kinase

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Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin

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The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

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The switch I region of Rheb is critical for its interaction with FKBP38.

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Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins

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Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane

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A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38.

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The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation

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Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

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Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

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inferred from DOI database lookup

7 January 2021

based on heuristic

Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

1 reference

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