Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2 (Q24323910)

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2 January 2020

title

Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2 (English)

1 reference

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WNK lysine deficient protein kinase 2

2 January 2020

main subject

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negative regulation of ERK1 and ERK2 cascade

GOA release 2020-03-11

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GOA release 2020-03-11

author

Paulo Matos

3

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2 January 2020

Peter Jordan

9

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2 January 2020

author name string

Moniz S

1

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2 January 2020

Veríssimo F

2

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2 January 2020

Brazão R

4

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2 January 2020

Silva E

5

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2 January 2020

Kotelevets L

6

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2 January 2020

Chastre E

7

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2 January 2020

Gespach C

8

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2 January 2020

language of work or name

English

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publication date

30 July 2007

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2 January 2020

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2 January 2020

volume

26

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2 January 2020

issue

41

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2 January 2020

page(s)

6071-6081

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Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells

2 January 2020

cites work

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High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

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Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

21 January 2018

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7 January 2021

PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.

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Mutations of the BRAF gene in human cancer

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The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity.

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7 January 2021

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

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7 January 2021

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

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Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter

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7 January 2021

Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension

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7 January 2021

The discovery of receptor tyrosine kinases: targets for cancer therapy

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth

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7 January 2021

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells

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7 January 2021

WNK kinases: molecular regulators of integrated epithelial ion transport

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7 January 2021

Human members of the eukaryotic protein kinase family

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7 January 2021

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

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7 January 2021

Properties of WNK1 and implications for other family members

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7 January 2021

The protein kinase complement of the human genome

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

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7 January 2021

Expression of Rac1b stimulates NF-kappaB-mediated cell survival and G1/S progression

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7 January 2021

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

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7 January 2021

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

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7 January 2021

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

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7 January 2021

A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

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7 January 2021

MEK1 activation by PAK: a novel mechanism

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7 January 2021

Cancer targets in the Ras pathway

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7 January 2021

Characterization of human colon cancer antigens recognized by autologous antibodies

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7 January 2021

Targeting the mitogen-activated protein kinase cascade to treat cancer

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7 January 2021

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

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7 January 2021

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

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7 January 2021

Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway

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7 January 2021

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

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7 January 2021

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

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7 January 2021

The RAF proteins take centre stage

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7 January 2021

Human hypertension caused by mutations in WNK kinases

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7 January 2021

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

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7 January 2021

WNK1 activates SGK1 to regulate the epithelial sodium channel.

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7 January 2021

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

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7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210706

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17667937%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 January 2020

0 references

1 reference