Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation (Q24541447)

6 July 2017

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation (English)

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6 July 2017

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GOA release 2020-03-11

Presenilin 1

1 reference

GOA release 2020-03-11

11

Paul Greengard

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6 July 2017

Dongming Cai

1

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6 July 2017

William J Netzer

2

1 reference

6 July 2017

Minghao Zhong

3

1 reference

6 July 2017

Yixin Lin

4

1 reference

6 July 2017

Guangwei Du

5

1 reference

6 July 2017

Michael Frohman

6

1 reference

6 July 2017

David A Foster

7

1 reference

6 July 2017

Sangram S Sisodia

8

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6 July 2017

Huaxi Xu

9

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6 July 2017

Fred S Gorelick

10

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6 July 2017

language of work or name

English

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publication date

31 January 2006

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Proceedings of the National Academy of Sciences of the United States of America

6 July 2017

6

1 reference

based on heuristic

inferred from page(s)

published in

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6 July 2017

103

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6 July 2017

6

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6 July 2017

1941-1946

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describes a project that uses

6 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1413665/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis

24 March 2017

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Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

24 March 2017

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

24 March 2017

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Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

24 March 2017

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

24 March 2017

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Presenilin is required for activity and nuclear access of Notch in Drosophila

24 March 2017

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

24 March 2017

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

24 March 2017

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

24 March 2017

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Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

7 April 2017

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Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1.

27 September 2017

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Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components

27 September 2017

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

27 September 2017

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A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

27 September 2017

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

27 September 2017

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

27 September 2017

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Intracellular localization of phospholipase D1 in mammalian cells

27 September 2017

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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

27 September 2017

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The presenilins in Alzheimer's disease--proteolysis holds the key.

27 September 2017

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Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

27 September 2017

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Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

27 September 2017

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

27 September 2017

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

27 September 2017

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Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells

27 September 2017

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Phospholipase D-catalyzed hydrolysis of phosphatidylcholine provides the choline precursor for acetylcholine synthesis in a human neuronal cell line

27 September 2017

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Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

27 September 2017

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Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells

27 September 2017

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Reduced phospholipase D activity in brain tissue samples from Alzheimer's disease patients.

27 September 2017

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Alzheimer's disease. A firm base for drug development.

30 May 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510708103

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

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Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

21 January 2018

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Lack of requirement for presenilin1 in Notch1 signaling.

21 January 2018

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Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16449386

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0510708103

1 reference

6 July 2017

0 references

1 reference

6 July 2017

1 reference