Switching Akt: from survival signaling to deadly response (Q24632379)

No death without life: vital functions of apoptotic effectors

Europe PubMed Central

title

Switching Akt: from survival signaling to deadly response (English)

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Marek Los

1

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author name string

Subbareddy Maddika

series ordinal

2

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Bettina Erb

series ordinal

3

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Klaus Schulze-Osthoff

series ordinal

4

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language of work or name

English

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publication date

May 2009

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published in

BioEssays

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volume

31

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issue

5

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page(s)

492-5

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cites work

1 reference

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AKT/PKB signaling: navigating downstream

7 April 2017

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

7 April 2017

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c-MYC: more than just a matter of life and death

7 April 2017

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Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase

7 April 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 April 2017

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PI3K pathway alterations in cancer: variations on a theme

7 April 2017

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

7 April 2017

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Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.

7 April 2017

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

27 September 2017

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The dark side of a tumor suppressor: anti-apoptotic p53.

27 September 2017

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Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

27 September 2017

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Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability

27 September 2017

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The multiple battles fought by anti-apoptotic p21.

27 September 2017

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Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

27 September 2017

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Identification of a tumour suppressor network opposing nuclear Akt function

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Akt-dependent transformation: there is more to growth than just surviving

27 September 2017

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The Akt-mTOR tango and its relevance to cancer

27 September 2017

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Connecting proliferation and apoptosis in development and disease

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Caspases: more than just killers?

27 September 2017

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

27 September 2017

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

27 September 2017

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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

30 May 2018

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Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species

30 May 2018

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30 May 2018

Identifiers

DOI

10.1002/BIES.200900005

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633405

633405

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1 reference

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