Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases (Q24644954)

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Europe PubMed Central

title

Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases (English)

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1 reference

Xiang Li

1

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He Li

series ordinal

2

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Xiao-Jiang Li

series ordinal

3

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language of work or name

English

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publication date

November 2008

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published in

Brain Research Reviews

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volume

59

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issue

1

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page(s)

245-52

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cites work

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7 April 2017

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7 April 2017

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Trinucleotide Repeat Disorders

7 April 2017

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Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

7 April 2017

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

27 September 2017

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Proteasomes cleave at multiple sites within polyglutamine tracts: activation by PA28gamma(K188E).

27 September 2017

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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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The proteasome and its role in nuclear protein maintenance.

27 September 2017

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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

27 September 2017

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Multiple pathways contribute to the pathogenesis of Huntington disease

27 September 2017

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27 September 2017

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27 September 2017

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Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

27 September 2017

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Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

27 September 2017

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

27 September 2017

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

27 September 2017

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27 September 2017

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27 September 2017

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Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

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Global changes to the ubiquitin system in Huntington's disease.

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Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans

28 November 2018

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Rapamycin pre-treatment protects against apoptosis

28 November 2018

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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

28 November 2018

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

28 November 2018

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Generalized brain and skin proteasome inhibition in Huntington's disease

28 November 2018

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Proteasome degrades soluble expanded polyglutamine completely and efficiently

28 November 2018

1 reference

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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

28 November 2018

1 reference

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Neuronal induction of the immunoproteasome in Huntington's disease.

28 November 2018

1 reference

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Autophagy regulates the processing of amino terminal huntingtin fragments

28 November 2018

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A transgenic mouse model of the ubiquitin/proteasome system

28 November 2018

1 reference

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Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

28 November 2018

1 reference

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Isolation and characterization of cytosolic and membrane-bound deubiquitinylating enzymes from bovine brain

28 November 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

28 November 2018

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Proteolysis: from the lysosome to ubiquitin and the proteasome

28 November 2018

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