Targeting the PI3K signaling pathway in cancer (Q24647554)

Current Opinion in Genetics & Development

Europe PubMed Central

title

Targeting the PI3K signaling pathway in cancer (English)

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1

Kwok-Kin Wong

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Lewis C. Cantley

object named as

Lewis C Cantley

series ordinal

3

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author name string

Jeffrey A Engelman

series ordinal

2

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language of work or name

English

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publication date

February 2010

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published in

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volume

20

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page(s)

87-90

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issue

1

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cites work

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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

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Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

7 April 2017

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

7 April 2017

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

7 April 2017

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

7 April 2017

1 reference

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

7 April 2017

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The phosphoinositide 3-kinase pathway

7 April 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

7 April 2017

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Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion

7 April 2017

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BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

7 April 2017

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

7 April 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 April 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

7 April 2017

1 reference

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PI3K pathway alterations in cancer: variations on a theme

7 April 2017

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

7 April 2017

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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

27 September 2017

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

27 September 2017

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In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

27 September 2017

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Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

27 September 2017

1 reference

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Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822054

Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

27 September 2017

1 reference

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Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

27 September 2017

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Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822054

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822054

Oncogenic PI3K and its role in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822054

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822054

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2822054

Oncogenic mutations of PIK3CA in human cancers

27 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20006486

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.GDE.2009.11.002

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1476657

1476657

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1 reference

1 reference