Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP (Q24650130)

5

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author name string

Chul Won Lee

1

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Maria A Martinez-Yamout

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H Jane Dyson

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

4

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language of work or name

English

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publication date

17 March 2009

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published in

Biochemistry

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volume

48

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issue

10

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page(s)

2115-24

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cites work

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Synergistic activation of transcription by CBP and p53

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Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

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Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain

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p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Recruitment of p300/CBP in p53-dependent signal pathways

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Phosphorylated CREB binds specifically to the nuclear protein CBP

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Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis

7 April 2017

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Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes

28 September 2017

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Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300.

28 September 2017

1 reference

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Mechanism of coupled folding and binding of an intrinsically disordered protein

28 September 2017

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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

28 September 2017

1 reference

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Post-translational modification of p53 in tumorigenesis

28 September 2017

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p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A.

28 September 2017

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The MDM2-p53 interaction.

28 September 2017

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The N-terminal domain of p53 is natively unfolded.

28 September 2017

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Regulation of p53 responses by post-translational modifications

28 September 2017

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Molecular mechanism of the interaction between MDM2 and p53.

28 September 2017

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p300/CBP/p53 interaction and regulation of the p53 response

28 September 2017

1 reference

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Definition of the p53 functional domains necessary for inducing apoptosis

28 September 2017

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HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

28 September 2017

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

28 September 2017

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

28 September 2017

1 reference

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p300 and CBP: partners for life and death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

A novel two-site binding equation presented in terms of the total ligand concentration.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Structural Basis for Cooperative Transcription Factor Binding to the CBP Coactivator

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

KIX-Mediated Assembly of the CBP−CREB−HTLV-1 Tax Coactivator−Activator Complex

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Cross-regulation of T cell growth factor expression by p53 and the Tax oncogene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Latent and active p53 are identical in conformation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765525

CBP as a transcriptional coactivator of c-Myb

28 November 2018

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12 December 2020

Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

1 reference

12 December 2020

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

1 reference

12 December 2020

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein

1 reference

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

12 December 2020

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

12 December 2020

Molecular recognition of the human coactivator CBP by the HIV-1 transcriptional activator Tat

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12 December 2020

Identifiers

DOI

10.1021/BI802055V

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1 reference

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PubMed publication ID

19220000

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