Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome (Q24677071)

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22 December 2019

title

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome (English)

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22 December 2019

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1 reference

3

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22 December 2019

author name string

James D Johnson

1

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22 December 2019

Ernesto Bernal-Mizrachi

2

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22 December 2019

Zhiqiang Han

4

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22 December 2019

Tatyana B Kalynyak

5

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22 December 2019

Hong Li

6

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22 December 2019

Jennifer L Beith

7

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22 December 2019

Julia Gross

8

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22 December 2019

Garth L Warnock

9

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22 December 2019

R Reid Townsend

10

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22 December 2019

M Alan Permutt

11

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22 December 2019

Kenneth S Polonsky

12

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22 December 2019

language of work or name

English

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publication date

8 December 2006

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22 December 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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22 December 2019

volume

103

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22 December 2019

issue

51

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22 December 2019

page(s)

19575-19580

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Overexpression of the coactivator bridge-1 results in insulin deficiency and diabetes

22 December 2019

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7 April 2017

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The coactivator Bridge-1 increases transcriptional activation by pancreas duodenum homeobox-1 (PDX-1)

7 April 2017

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Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

7 April 2017

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7 April 2017

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PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

7 April 2017

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7 April 2017

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Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

7 April 2017

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

28 September 2017

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Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells

28 September 2017

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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion

28 September 2017

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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

28 September 2017

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28 September 2017

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Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

28 September 2017

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28 September 2017

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28 September 2017

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30 May 2018

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Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

28 November 2018

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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin

28 November 2018

1 reference

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IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

28 November 2018

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Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway

28 November 2018

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beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

28 November 2018

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Direct measurement of pulsatile insulin secretion from the portal vein in human subjects.

28 November 2018

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Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

28 November 2018

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Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

28 November 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

28 November 2018

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Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal

28 November 2018

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12 December 2020

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1 reference

12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

12 December 2020

Islet filtration: a simple and rapid new purification procedure that avoids ficoll and improves islet mass and function

1 reference

12 December 2020

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

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12 December 2020

Suppressed insulin signaling and increased apoptosis in CD38-null islets

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0604208103

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17158802%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

ADS bibcode

2006PNAS..10319575J

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17158802%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

2 references