Emerging Threats in Antifungal-Resistant Fungal Pathogens (Q26750816)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1

Dominique Sanglard

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language of work or name

English

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publication date

2016

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published in

Frontiers in Medicine

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json

MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?

2 June 2020

cites work

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Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae

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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

7 April 2017

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Echinocandin resistance: an emerging clinical problem?

7 April 2017

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Fitness trade-offs restrict the evolution of resistance to amphotericin B

7 April 2017

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Hidden killers: human fungal infections

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7 April 2017

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Defining the frontiers between antifungal resistance, tolerance and the concept of persistence.

7 April 2017

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Echinocandin Resistance in Candida

28 September 2017

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Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms

28 September 2017

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Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy.

28 September 2017

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Update on Antifungal Drug Resistance

28 September 2017

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Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations

28 September 2017

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Environmental isolates of azole-resistant Aspergillus fumigatus in Germany

28 September 2017

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Community participation in biofilm matrix assembly and function

28 September 2017

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Drug-resistant Candida glabrata infection in cancer patients

28 September 2017

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Fungal biofilms, drug resistance, and recurrent infection

28 September 2017

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Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?

28 September 2017

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Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance

28 September 2017

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Amphotericin forms an extramembranous and fungicidal sterol sponge.

28 September 2017

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Breakpoints for antifungal agents: an update from EUCAST focussing on echinocandins against Candida spp. and triazoles against Aspergillus spp.

28 September 2017

1 reference

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Impact of new antifungal breakpoints on antifungal resistance in Candida species

28 September 2017

1 reference

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Update on antifungal resistance in Aspergillus and Candida.

28 September 2017

1 reference

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Azole resistance in Aspergillus fumigatus: a growing public health concern.

28 September 2017

1 reference

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Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals

28 September 2017

1 reference

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Candida albicans biofilms: building a heterogeneous, drug-tolerant environment

28 September 2017

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Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations

28 September 2017

1 reference

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Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011.

28 September 2017

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Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012

28 September 2017

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Yeast ATP-binding cassette transporters conferring multidrug resistance

28 September 2017

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Amino acid substitutions in the Candida albicans sterol Δ5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence

28 September 2017

1 reference

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Azole resistance by loss of function of the sterol Δ⁵,⁶-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence

28 September 2017

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Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment

28 September 2017

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Current perspectives on echinocandin class drugs

28 September 2017

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Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment

28 September 2017

1 reference

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Azole resistance in Aspergillus fumigatus: a new challenge in the management of invasive aspergillosis?

28 September 2017

1 reference

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Identification and characterization of four azole-resistant erg3 mutants of Candida albicans

28 September 2017

1 reference

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A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Comparison of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Etest methods with the CLSI broth microdilution method for echinocandin susceptibility testing of Candida species.

28 September 2017

1 reference

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Phylogenetic analysis of fungal ABC transporters.

28 September 2017

1 reference

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Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

28 September 2017

1 reference

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Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans

28 September 2017

1 reference

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Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient.

28 September 2017

1 reference

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Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi

28 September 2017

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Fungal PDR transporters: Phylogeny, topology, motifs and function.

28 September 2017

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Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

28 September 2017

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Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007.

28 September 2017

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Efflux in fungi: la pièce de résistance

28 September 2017

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MFS transportome of the human pathogenic yeast Candida albicans

28 September 2017

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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

28 September 2017

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Mutations in the fks1 gene in Candida albicans, C. tropicalis, and C. krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility Testing

28 September 2017

1 reference

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Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

28 September 2017

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A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

28 September 2017

1 reference

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A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility

28 September 2017

1 reference

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Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae

28 September 2017

1 reference

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Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies.

28 September 2017

1 reference

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Evolution of gene families: the multidrug resistance transporter genes in five related yeast species

28 September 2017

1 reference

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A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins

28 September 2017

1 reference

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Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus

28 September 2017

1 reference

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Candida biofilms: an update

28 September 2017

1 reference

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TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.

28 September 2017

1 reference

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Molecular mechanisms of primary resistance to flucytosine in Candida albicans

28 September 2017

1 reference

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Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans

28 September 2017

1 reference

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Molecular mechanisms of itraconazole resistance in Candida dubliniensis

28 September 2017

1 reference

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Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents

28 September 2017

1 reference

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Variation in Susceptibility of Bloodstream Isolates of Candida glabrata to Fluconazole According to Patient Age and Geographic Location

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

28 September 2017

1 reference

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A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

28 September 2017

1 reference

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Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

28 September 2017

1 reference

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Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformans

28 September 2017

1 reference

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A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Correlation of fluconazole MICs with clinical outcome in cryptococcal infection

28 September 2017

1 reference

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An evaluation of the in vitro activity of terbinafine

28 September 2017

1 reference

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The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4791369

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

28 September 2017

1 reference

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Infectious Disease. How to bolster the antifungal pipeline

28 September 2017

1 reference

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First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

28 September 2017

1 reference

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Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

31 May 2018

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Support for the EUCAST and revised CLSI fluconazole clinical breakpoints by Sensititre® YeastOne® for Candida albicans: a prospective observational cohort study

31 May 2018

1 reference

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Comparison of EUCAST and CLSI broth microdilution methods for the susceptibility testing of 10 systemically active antifungal agents when tested against Candida spp.

31 May 2018

1 reference

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Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database.

31 May 2018

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https://api.crossref.org/works/10.3389%2FFMED.2016.00011

EUCAST technical note on Candida and micafungin, anidulafungin and fluconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

EUCAST technical note on fluconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Wild-type MIC distributions and epidemiologic cutoff values for fluconazole, posaconazole, and voriconazole when testing Cryptococcus neoformans as determined by the CLSI broth microdilution method.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

A novel mechanism of fluconazole resistance associated with fluconazole sequestration in Candida albicans isolates from a myelofibrosis patient

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Mutational analysis of flucytosine resistance in Candida glabrata

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Triazole fungicides and the selection of resistance to medical triazoles in the opportunistic mould Aspergillus fumigatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFMED.2016.00011

Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27014694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular mechanisms of resistance to 5-fluorocytosine in laboratory mutants of Candida glabrata

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27014694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FMED.2016.00011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27014694%20AND%20SRC:MED&resulttype=core&format=json