New Features about Tau Function and Dysfunction (Q26750922)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Felix Hernandez

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Jesús Ávila de Grado

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Miguel Medina

1

0 references

Félix Hernández

2

0 references

Jesús Avila

3

0 references

language of work or name

English

0 references

publication date

2016

0 references

19 April 2016

2 references

11 December 2019

19 December 2019

4 references

11 December 2019

19 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

4 June 2020

page(s)

21

0 references

copyright license

2 references

11 December 2019

19 December 2019

0 references

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

1 reference

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

7 April 2017

1 reference

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Transmission and spreading of tauopathy in transgenic mouse brain

7 April 2017

1 reference

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A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease

7 April 2017

1 reference

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

A protein factor essential for microtubule assembly

7 April 2017

1 reference

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Neurodegeneration and microtubule dynamics: death by a thousand cuts

7 April 2017

1 reference

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Molecular mechanisms of dendrite stability

7 April 2017

1 reference

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

7 April 2017

1 reference

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

7 April 2017

1 reference

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Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

7 April 2017

1 reference

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Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

7 April 2017

1 reference

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Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Trans-synaptic spread of tau pathology in vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Altered microtubule organization in small-calibre axons of mice lacking tau protein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Propagation of tau pathology in a model of early Alzheimer's disease

7 April 2017

1 reference

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

The distribution of tau in the mammalian central nervous system

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

28 September 2017

1 reference

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Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Regulation of human MAPT gene expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Tau phosphorylation at serine 396 residue is required for hippocampal LTD

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

The dendritic spine story: an intriguing process of discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Cellular factors modulating the mechanism of tau protein aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Further understanding of tau phosphorylation: implications for therapy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

A phase II trial of tideglusib in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model

28 September 2017

1 reference

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Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease

28 September 2017

1 reference

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Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma

28 September 2017

1 reference

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Invited review: Prion-like transmission and spreading of tau pathology

28 September 2017

1 reference

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Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Acetylation: a new key to unlock tau's role in neurodegeneration

28 September 2017

1 reference

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The role of extracellular Tau in the spreading of neurofibrillary pathology.

28 September 2017

1 reference

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New perspectives on the role of tau in Alzheimer's disease. Implications for therapy.

28 September 2017

1 reference

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A role for tau at the synapse in Alzheimer's disease pathogenesis.

28 September 2017

1 reference

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Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

28 September 2017

1 reference

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The microtubule-associated tau protein has intrinsic acetyltransferase activity

28 September 2017

1 reference

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Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing

28 September 2017

1 reference

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

28 September 2017

1 reference

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Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

28 September 2017

1 reference

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Trans-cellular propagation of Tau aggregation by fibrillar species

28 September 2017

1 reference

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

28 September 2017

1 reference

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Recent developments in tau-based therapeutics for neurodegenerative diseases

28 September 2017

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Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration

28 September 2017

1 reference

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Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.

28 September 2017

1 reference

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Extracellular tau is toxic to neuronal cells.

28 September 2017

1 reference

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

28 September 2017

1 reference

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Down syndrome and genetics - a case of linked histories.

28 September 2017

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Mutations causing neurodegenerative tauopathies

28 September 2017

1 reference

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Role of tau protein in both physiological and pathological conditions.

28 September 2017

1 reference

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Tau gene mutations and neurodegeneration.

28 September 2017

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Competition for microtubule-binding with dual expression of tau missense and splice isoforms

28 September 2017

1 reference

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Microtubule-associated proteins: their potential role in determining neuronal morphology

28 September 2017

1 reference

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

28 September 2017

1 reference

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Tau protein function in living cells

28 September 2017

1 reference

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Structural characterization of the core of the paired helical filament of Alzheimer disease

28 September 2017

1 reference

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

28 September 2017

1 reference

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Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

28 September 2017

1 reference

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Primary structure of high molecular weight tau present in the peripheral nervous system

28 September 2017

1 reference

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Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

28 September 2017

1 reference

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NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

28 September 2017

1 reference

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Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

28 September 2017

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Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

31 May 2018

1 reference

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Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

31 May 2018

1 reference

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Localization of the tubulin binding site for tau protein.

31 May 2018

1 reference

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Tau factor polymers are similar to paired helical filaments of Alzheimer's disease

31 May 2018

1 reference

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

31 May 2018

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Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

31 May 2018

1 reference

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Increased tau messenger RNA in Alzheimer's disease hippocampus

31 May 2018

1 reference

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Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

31 May 2018

1 reference

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Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.

31 May 2018

1 reference

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Microtubule assembly in vitro. Purification of assembly-promoting factors.

31 May 2018

1 reference

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

31 May 2018

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Pathological tau disrupts ongoing network activity

21 January 2018

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Thr175-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr231 in vitro.

21 January 2018

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Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.

21 January 2018

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A Novel MAPT Mutation Causing Corticobasal Syndrome Led by Progressive Apraxia of Speech.

21 January 2018

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Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

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The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties

21 January 2018

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Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

21 January 2018

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Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020021

Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020021

Anti-tau antibodies: hitting the target.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020021

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020021

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FBIOM6020021

Argyrophilic grain pathology as a natural model of tau propagation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919916

Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27104579

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/27104579

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/BIOM6020021

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

27104579

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27104579%20AND%20SRC:MED&resulttype=core&format=json