NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease (Q41427586)

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scientific article published on 15 February 2015

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English	NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease	scientific article published on 15 February 2015

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scholarly article

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Europe PubMed Central

30 September 2017

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease (English)

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Europe PubMed Central

30 September 2017

Alzheimer's disease

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3

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Antonella Borreca

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Simona D'Aguanno

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Vanessa Nicolin

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Giuseppina Amadoro

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author name string

F Florenzano

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A Bobba

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M T Ciotti

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F Natale

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F Della Valle

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A Manca

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C Ferraina

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M Feligioni

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R Bussani

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M Ammassari-Teule

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P Calissano

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V Corsetti

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publication date

15 February 2015

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Human Molecular Genetics

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3058-3081

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3 June 2020

Phosphorylation and cleavage of tau in non-AD tauopathies.

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Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

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Proteolytic processing of tau.

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Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

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21 January 2018

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

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Synaptic mitochondrial pathology in Alzheimer's disease

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A role for tau at the synapse in Alzheimer's disease pathogenesis.

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The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

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Role of the ubiquitin proteasome system in Alzheimer's disease

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Ubiquitin and the synapse.

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

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21 January 2018

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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21 January 2018

Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

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21 January 2018

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

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Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

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21 January 2018

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

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Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

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21 January 2018

Neurodegeneration as a consequence of failed mitochondrial maintenance

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Why size matters - balancing mitochondrial dynamics in Alzheimer's disease

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The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

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21 January 2018

Autophagocytosis of mitochondria is prominent in Alzheimer disease.

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21 January 2018

Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease.

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21 January 2018

Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model.

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21 January 2018

Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies

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Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease

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Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis

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After the banquet: mitochondrial biogenesis, mitophagy, and cell survival

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Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation

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Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy

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Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation.

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Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells

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Dynamic survey of mitochondria by ubiquitin.

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A role for ubiquitin in selective autophagy

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Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway

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Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics

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Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

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Mitochondrial quality control by the ubiquitin-proteasome system

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ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

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The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

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Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons

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Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons

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21 January 2018

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

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21 January 2018

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

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21 January 2018

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

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21 January 2018

Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

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Axonal transport of two major components of the ubiquitin system: free ubiquitin and ubiquitin carboxyl-terminal hydrolase PGP 9.5

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

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Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

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Reversal of long-term dendritic spine alterations in Alzheimer disease models

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Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

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Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia

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Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

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Profiling of Parkin-binding partners using tandem affinity purification

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Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons.

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NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

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Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models.

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Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

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Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation

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The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

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A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.

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Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.

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AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

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The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

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Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

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Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.

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Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

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Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

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Parkin interacts with Ambra1 to induce mitophagy

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Assessing neuronal bioenergetic status

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How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

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Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

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Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

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Hexokinase activity is required for recruitment of parkin to depolarized mitochondria

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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

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Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

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Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

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Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

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Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

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Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice

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Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease

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Synaptosome proteomics

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21 January 2018

Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition.

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21 January 2018

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits

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Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

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Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

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Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

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Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

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Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

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21 January 2018

Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

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21 January 2018

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial dismissal in mammals, from protein degradation to mitophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin promotes intracellular Abeta1-42 clearance

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Dopamine covalently modifies and functionally inactivates parkin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Regulation of parkin and PINK1 by neddylation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The role of estrogens on the proliferation of human breast tumor cells (MCF-7).

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Reactive oxygen species generation is modulated by mitochondrial kinases: correlation with mitochondrial antioxidant peroxidases in rat tissues

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

alphaCaMKII autophosphorylation levels differ depending on subcellular localization

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

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