HIV-Host Interactions: Implications for Vaccine Design (Q26765966)

Beatrice H Hahn

6

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Persephone Borrow

Persephone Borrow

7

0 references

Joseph Sodroski

5

Joseph Sodroski

0 references

Garnett Kelsoe

4

Garnett Kelsoe

0 references

Barton Haynes

1

Barton F Haynes

0 references

George M. Shaw

2

George M Shaw

0 references

Andrew James McMichael

8

Design and pre-clinical evaluation of a universal HIV-1 vaccine

Andrew J McMichael

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language of work or name

English

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publication date

9 March 2016

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published in

Cell Host & Microbe

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volume

19

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page(s)

292-303

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issue

3

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cites work

1 reference

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Designing synthetic vaccines for HIV

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7 April 2017

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Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

7 April 2017

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Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

7 April 2017

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Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

7 April 2017

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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

7 April 2017

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

7 April 2017

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

7 April 2017

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

7 April 2017

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Elicitation of structure-specific antibodies by epitope scaffolds

7 April 2017

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Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

7 April 2017

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Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

7 April 2017

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HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

7 April 2017

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

7 April 2017

1 reference

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Immune-correlates analysis of an HIV-1 vaccine efficacy trial

7 April 2017

1 reference

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Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

7 April 2017

1 reference

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Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.

7 April 2017

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Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design

28 September 2017

1 reference

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Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition

28 September 2017

1 reference

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Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

28 September 2017

1 reference

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Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses

28 September 2017

1 reference

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Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials

28 September 2017

1 reference

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Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

28 September 2017

1 reference

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Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans

28 September 2017

1 reference

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HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

28 September 2017

1 reference

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Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

28 September 2017

1 reference

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Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

28 September 2017

1 reference

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HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

28 September 2017

1 reference

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Success and failure of the cellular immune response against HIV-1.

28 September 2017

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HIV-1 and interferons: who's interfering with whom?

28 September 2017

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A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

28 September 2017

1 reference

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Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost

28 September 2017

1 reference

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Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

28 September 2017

1 reference

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Immune checkpoint blockade in hematologic malignancies

28 September 2017

1 reference

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Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients

28 September 2017

1 reference

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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

28 September 2017

1 reference

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T follicular helper cell differentiation, function, and roles in disease

28 September 2017

1 reference

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Polyreactivity and autoreactivity among HIV-1 antibodies

28 September 2017

1 reference

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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

28 September 2017

1 reference

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HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria

28 September 2017

1 reference

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Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies

28 September 2017

1 reference

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Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

28 September 2017

1 reference

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HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck

28 September 2017

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Proteome-wide analysis of HIV-specific naive and memory CD4(+) T cells in unexposed blood donors

28 September 2017

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AIDS/HIV. Host controls of HIV neutralizing antibodies

28 September 2017

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Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective

28 September 2017

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Specificity and 6-month durability of immune responses induced by DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles

28 September 2017

1 reference

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Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

28 September 2017

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28 September 2017

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Relative resistance of HIV-1 founder viruses to control by interferon-alpha

28 September 2017

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28 September 2017

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Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41.

28 September 2017

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Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

28 September 2017

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Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.

28 September 2017

1 reference

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Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.

28 September 2017

1 reference

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Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

28 September 2017

1 reference

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Immune clearance of highly pathogenic SIV infection

28 September 2017

1 reference

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Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10

28 September 2017

1 reference

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Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery

28 September 2017

1 reference

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Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms

28 September 2017

1 reference

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Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

28 September 2017

1 reference

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Phenotypic properties of transmitted founder HIV-1

28 September 2017

1 reference

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Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape

28 September 2017

1 reference

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Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

28 September 2017

1 reference

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Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

28 September 2017

1 reference

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HIV and HLA class I: an evolving relationship

28 September 2017

1 reference

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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

28 September 2017

1 reference

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Definition of the viral targets of protective HIV-1-specific T cell responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

28 September 2017

1 reference

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Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection

28 September 2017

1 reference

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Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine

28 September 2017

1 reference

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Correlates of protection induced by vaccination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Evolutionary analysis of the dynamics of viral infectious disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Glycerol monolaurate prevents mucosal SIV transmission

28 September 2017

1 reference

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HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis

28 September 2017

1 reference

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Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

HIV-1 group M conserved elements vaccine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

The normal and malignant germinal centre

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Antigen-induced B-cell death and elimination during germinal-centre immune responses

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Direct observation of ligand recognition by T cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823811

Cancer immunology and immunotherapy. Realizing the promise. Introduction

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26922989

12 December 2020

inferred from PubMed ID database lookup

Functional analysis of cloned germinal center CD4+ cells with natural killer cell-related features. Divergence from typical T helper cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26922989

12 December 2020

inferred from PubMed ID database lookup

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CHOM.2016.02.002

7 January 2021

inferred from DOI database lookup

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CHOM.2016.02.002

7 January 2021