Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? (Q26775940)

1

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Wei Ney Yap

2

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Frank Arfuso

3

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Shreya Kar

4

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Chao Wang

5

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Wanpei Cai

6

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Arunasalam M Dharmarajan

7

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Alan Prem Kumar

World Journal of Gastroenterology

9

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language of work or name

English

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publication date

21 November 2015

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published in

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volume

21

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issue

43

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page(s)

12261-73

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cites work

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Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions.

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Targeting PI3K in Cancer: Any Good News?

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28 September 2017

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Oncogenic AKTivation of translation as a therapeutic target

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Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake

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Forkhead transcription factors: key players in health and disease

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28 September 2017

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Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt

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Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

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Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

28 September 2017

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28 September 2017

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Mutation of the PIK3CA gene in anaplastic thyroid cancer.

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The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

28 September 2017

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Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition

28 September 2017

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The activation of Akt/PKB signaling pathway and cell survival.

28 September 2017

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Regulation of sensitivity to TRAIL by the PTEN tumor suppressor.

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Wortmannin, a microbial product inhibitor of myosin light chain kinase

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

31 May 2018

The PI3K-PKB/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Prognostic implication of TSC1 and mTOR expression in gastric carcinoma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Activated Akt as an indicator of prognosis in gastric cancer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

Promoter methylation and silencing of PTEN in gastric carcinoma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649111

PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26604635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26604635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26604635