Making new contacts: the mTOR network in metabolism and signalling crosstalk (Q38189969)

30 August 2017

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title

Making new contacts: the mTOR network in metabolism and signalling crosstalk (English)

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30 August 2017

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Michael N Hall

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

1 March 2014

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Nature Reviews Molecular Cell Biology

30 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

155-162

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrm3757

7 June 2020

exact match

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cites work

TOR signaling in growth and metabolism

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mTOR signaling in growth control and disease

31 March 2020

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

31 March 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

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Rheb binds and regulates the mTOR kinase

31 March 2020

1 reference

Molecular mechanisms of mTOR-mediated translational control

31 March 2020

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mTOR, translation initiation and cancer

31 March 2020

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Amino acid signalling upstream of mTOR

31 March 2020

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Tuberous sclerosis complex: linking cancer to metabolism

31 March 2020

1 reference

Activation of mTORC2 by association with the ribosome

31 March 2020

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TOR complex 2: a signaling pathway of its own.

31 March 2020

1 reference

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

31 March 2020

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

31 March 2020

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Distinct perturbation of the translatome by the antidiabetic drug metformin

31 March 2020

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A unifying model for mTORC1-mediated regulation of mRNA translation.

31 March 2020

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

31 March 2020

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

31 March 2020

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Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

31 March 2020

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

31 March 2020

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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

31 March 2020

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Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

31 March 2020

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

31 March 2020

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

31 March 2020

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

31 March 2020

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S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover

31 March 2020

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

31 March 2020

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

31 March 2020

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

31 March 2020

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mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

31 March 2020

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The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

31 March 2020

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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

31 March 2020

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

31 March 2020

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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

31 March 2020

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

31 March 2020

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Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation

31 March 2020

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

31 March 2020

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Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2

31 March 2020

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mTOR in aging, metabolism, and cancer

31 March 2020

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A Central role for mTOR in lipid homeostasis

31 March 2020

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The multifaceted role of mTORC1 in the control of lipid metabolism

31 March 2020

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Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

31 March 2020

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

31 March 2020

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

31 March 2020

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

31 March 2020

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

31 March 2020

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

31 March 2020

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

31 March 2020

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Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.

31 March 2020

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DAP1, a novel substrate of mTOR, negatively regulates autophagy

31 March 2020

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Termination of autophagy and reformation of lysosomes regulated by mTOR

31 March 2020

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

31 March 2020

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

31 March 2020

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

31 March 2020

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Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

31 March 2020

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Regulation of TFEB and V-ATPases by mTORC1.

31 March 2020

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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

31 March 2020

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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

31 March 2020

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YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

31 March 2020

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Elucidation of a universal size-control mechanism in Drosophila and mammals

31 March 2020

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Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

31 March 2020

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Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

31 March 2020

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Lipid signalling in disease.

31 March 2020

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The complex world of WNT receptor signalling

31 March 2020

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

31 March 2020

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Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

31 March 2020

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WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.

31 March 2020

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Notch signalling: a simple pathway becomes complex

31 March 2020

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Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

31 March 2020

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mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

31 March 2020

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Where is mTOR and what is it doing there?

31 March 2020

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Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.

31 March 2020

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

31 March 2020

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Regulation of TORC1 by Rag GTPases in nutrient response

31 March 2020

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

31 March 2020

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

31 March 2020

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

31 March 2020

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Glutaminolysis activates Rag-mTORC1 signaling.

31 March 2020

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HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

31 March 2020

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

31 March 2020

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Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

31 March 2020

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Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

31 March 2020

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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

31 March 2020

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Rapamycin passes the torch: a new generation of mTOR inhibitors

31 March 2020

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mTOR kinase structure, mechanism and regulation

31 March 2020

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