The activation of Akt/PKB signaling pathway and cell survival. (Q34405519)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784165%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

review article

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title

The activation of Akt/PKB signaling pathway and cell survival (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784165%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Gang Song

series ordinal

1

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9 January 2020

Gaoliang Ouyang

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784165%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Shideng Bao

series ordinal

3

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9 January 2020

publication date

1 January 2005

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784165%20AND%20SRC:MED&resulttype=core&format=json

Journal of Cellular and Molecular Medicine

9 January 2020

published in

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9 January 2020

volume

9

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9 January 2020

issue

1

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9 January 2020

page(s)

59-71

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15784165%20AND%20SRC:MED&resulttype=core&format=json

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

9 January 2020

cites work

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12 December 2020

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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12 December 2020

Induction of NF-kappaB by the Akt/PKB kinase

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12 December 2020

Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

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12 December 2020

Kinase phosphorylation: Keeping it all in the family

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12 December 2020

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

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12 December 2020

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

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12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

Control of apoptosis by Rel/NF-kappaB transcription factors

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12 December 2020

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

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12 December 2020

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

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12 December 2020

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

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12 December 2020

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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12 December 2020

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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12 December 2020

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

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12 December 2020

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

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12 December 2020

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

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12 December 2020

The protooncogene TCL1 is an Akt kinase coactivator

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12 December 2020

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

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12 December 2020

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

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12 December 2020

PTEN: life as a tumor suppressor

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12 December 2020

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

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12 December 2020

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

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12 December 2020

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

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12 December 2020

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

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12 December 2020

Regulation of Akt/PKB activation by tyrosine phosphorylation

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12 December 2020

c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of Tcells and is required for PKB-mediated protection from apoptosis

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12 December 2020

Growth factors can influence cell growth and survival through effects on glucose metabolism

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12 December 2020

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

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12 December 2020

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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12 December 2020

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

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12 December 2020

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

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12 December 2020

The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions

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12 December 2020

Ten years of protein kinase B signalling: a hard Akt to follow

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12 December 2020

Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation

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12 December 2020

Role for the adaptor protein Grb10 in the activation of Akt

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12 December 2020

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

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12 December 2020

The protein kinase B/Akt signalling pathway in human malignancy

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12 December 2020

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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12 December 2020

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

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12 December 2020

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

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12 December 2020

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

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12 December 2020

Binding of protein kinase B to the plakin family member periplakin

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12 December 2020

NF-kappaB regulation in the immune system

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12 December 2020

PKB binding proteins. Getting in on the Akt.

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12 December 2020

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

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12 December 2020

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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12 December 2020

Structure and zymogen activation of caspases

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12 December 2020

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

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12 December 2020

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

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12 December 2020

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

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12 December 2020

GSK-3: tricks of the trade for a multi-tasking kinase

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12 December 2020

Decision making by p53: life, death and cancer

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12 December 2020

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol

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12 December 2020

Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation

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12 December 2020

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

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12 December 2020

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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12 December 2020

Phosphoinositide 3-kinase signalling--which way to target?

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12 December 2020

Intrasteric regulation of MDM2.

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12 December 2020

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

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12 December 2020

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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12 December 2020

Akt2 Negatively Regulates Assembly of the POSH-MLK-JNK Signaling Complex

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12 December 2020

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

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12 December 2020

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

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12 December 2020

Targeting of the Akt/PKB kinase to the actin skeleton.

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12 December 2020

Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis.

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12 December 2020

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt

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12 December 2020

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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12 December 2020

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway

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12 December 2020

Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.

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12 December 2020

PDK1, the master regulator of AGC kinase signal transduction

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12 December 2020

Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells

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12 December 2020

Effect of overexpression and nuclear translocation of constitutively active PKB-alpha on cellular survival and proliferation in HepG2 cells

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12 December 2020

Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation

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12 December 2020

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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12 December 2020

Molecular cloning of a second form of rac protein kinase

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12 December 2020

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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12 December 2020

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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12 December 2020

Molecular cloning and expression of the major protein kinase C substrate of platelets

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12 December 2020

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

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12 December 2020

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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12 December 2020

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

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12 December 2020

Mechanism of activation of protein kinase B by insulin and IGF-1

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12 December 2020

Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

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12 December 2020

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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12 December 2020

cAMP stimulates protein kinase B in a Wortmannin-insensitive manner

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12 December 2020

Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27.

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12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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12 December 2020

Role of translocation in the activation and function of protein kinase B

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12 December 2020

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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12 December 2020

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

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12 December 2020

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

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12 December 2020

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

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12 December 2020

Caspases: enemies within

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12 December 2020

The Bcl-2 protein family: arbiters of cell survival

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12 December 2020

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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12 December 2020

Regulation of cell death protease caspase-9 by phosphorylation

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12 December 2020

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

12 December 2020

10.1111/J.1582-4934.2005.TB00337.X

Identifiers

DOI

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9 January 2020

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