Functional Role of G9a Histone Methyltransferase in Cancer (Q26781247)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26441991%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Functional Role of G9a Histone Methyltransferase in Cancer (English)

1 reference

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26 February 2020

1

1 reference

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26 February 2020

Jason S Lee

series ordinal

4

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26 February 2020

author name string

Karolina Windloch

series ordinal

2

1 reference

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26 February 2020

Frank Gannon

series ordinal

3

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26 February 2020

language of work or name

English

0 references

publication date

25 September 2015

1 reference

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26 February 2020

published in

Frontiers in Immunology

2 references

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7 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26441991%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

6

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26 February 2020

page(s)

487

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mTOR signaling in growth control and disease

26 February 2020

cites work

1 reference

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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

7 April 2017

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Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

7 April 2017

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

7 April 2017

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

7 April 2017

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Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

7 April 2017

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7 April 2017

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7 April 2017

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

7 April 2017

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Histone sumoylation is associated with transcriptional repression

7 April 2017

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MDC1 is a mediator of the mammalian DNA damage checkpoint

7 April 2017

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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

7 April 2017

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Methylation at arginine 17 of histone H3 is linked to gene activation

7 April 2017

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Translating the Histone Code

7 April 2017

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

7 April 2017

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The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats

7 April 2017

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Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells

7 April 2017

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Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction

7 April 2017

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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

7 April 2017

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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

7 April 2017

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Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

7 April 2017

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7 April 2017

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

7 April 2017

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The language of covalent histone modifications

7 April 2017

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Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.

7 April 2017

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Histone demethylation by a family of JmjC domain-containing proteins

7 April 2017

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7 April 2017

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7 April 2017

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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

7 April 2017

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7 April 2017

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7 April 2017

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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

7 April 2017

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Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

7 April 2017

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7 April 2017

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Epigenetics in human disease and prospects for epigenetic therapy

7 April 2017

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Active genes are tri-methylated at K4 of histone H3

7 April 2017

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Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

7 April 2017

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The diverse functions of histone lysine methylation

7 April 2017

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WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

28 September 2017

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Inhibition of H3K9 methyltransferase G9a repressed cell proliferation and induced autophagy in neuroblastoma cells

28 September 2017

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The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis.

28 September 2017

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The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

28 September 2017

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Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.

28 September 2017

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Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol

28 September 2017

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Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation

28 September 2017

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C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe.

28 September 2017

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Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

28 September 2017

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The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

28 September 2017

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A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

28 September 2017

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BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

28 September 2017

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The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation

28 September 2017

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Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

28 September 2017

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Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

28 September 2017

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28 September 2017

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Protein arginine methyltransferases and cancer

28 September 2017

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28 September 2017

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Altered histone modifications in cancer

28 September 2017

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Concise review: chromatin and genome organization in reprogramming.

28 September 2017

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BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells

28 September 2017

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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

28 September 2017

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G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

28 September 2017

1 reference

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Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties

28 September 2017

1 reference

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Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons

28 September 2017

1 reference

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H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

28 September 2017

1 reference

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Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene

28 September 2017

1 reference

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Negative regulation of hypoxic responses via induced Reptin methylation.

28 September 2017

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Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.

28 September 2017

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Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene.

28 September 2017

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A case study in cross-talk: the histone lysine methyltransferases G9a and GLP.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Functional analysis of histone methyltransferase g9a in B and T lymphocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Protein lysine methyltransferase G9a acts on non-histone targets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Automethylation of G9a and its implication in wider substrate specificity and HP1 binding

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Functional cooperation between HP1 and DNMT1 mediates gene silencing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Pivanex, a histone deacetylase inhibitor, induces changes in BCR-ABL expression and when combined with STI571, acts synergistically in a chronic myelocytic leukemia cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Histone H2AX phosphorylation induced by selective photolysis of BrdU-labeled DNA with UV light: relation to cell cycle phase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Targeted inhibition of V(D)J recombination by a histone methyltransferase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

RNA-directed de novo methylation of genomic sequences in plants.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Inhibition of demethylases by GSK-J1/J4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Non-radioactive protein lysine methyltransferase microplate assay based on reading domains.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Histone acetylation: chromatin in action

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4585248

Towards a Theoretical Biology

31 May 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

Histone deacetylase inhibition attenuates cardiac hypertrophy and fibrosis through acetylation of mineralocorticoid receptor in spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

Overexpression of G9a and MCM7 in oesophageal squamous cell carcinoma is associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2015.00487

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26441991

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of nucleosome core particles containing histone proteins made in bacteria

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26441991

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FIMMU.2015.00487

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26441991%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26441991%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

26441991

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26441991%20AND%20SRC:MED&resulttype=core&format=json