Role of endoglin in fibrosis and scleroderma (Q26821836)

Crossref

Maria Trojanowska

series ordinal

2

1 reference

Crossref

Peter ten Dijke

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

2012

1 reference

International Review of Cell and Molecular Biology

published in

1 reference

volume

297

1 reference

page(s)

295-308

1 reference

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

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Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

7 April 2017

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

7 April 2017

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

7 April 2017

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Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity

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Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

7 April 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

7 April 2017

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Up-regulation of endoglin, a TGF-beta-binding protein, in rats with experimental renal fibrosis induced by renal mass reduction

7 April 2017

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L- and S-endoglin differentially modulate TGFbeta1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

7 April 2017

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

7 April 2017

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Soluble endoglin contributes to the pathogenesis of preeclampsia

7 April 2017

1 reference

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New insights into TGF-beta-Smad signalling

7 April 2017

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Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling

7 April 2017

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Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts

7 April 2017

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Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells

7 April 2017

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Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II

7 April 2017

1 reference

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Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development

7 April 2017

1 reference

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A murine model of hereditary hemorrhagic telangiectasia

7 April 2017

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Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

7 April 2017

1 reference

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Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth

7 April 2017

1 reference

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Exploring anti-TGF-β therapies in cancer and fibrosis.

28 September 2017

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TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.

28 September 2017

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Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

28 September 2017

1 reference

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Endoglin-targeted cancer therapy

28 September 2017

1 reference

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Fibrosis and immune dysregulation in systemic sclerosis

28 September 2017

1 reference

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Cellular and molecular aspects of vascular dysfunction in systemic sclerosis

28 September 2017

1 reference

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Scleroderma: from pathophysiology to novel therapeutic approaches

28 September 2017

1 reference

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Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys

28 September 2017

1 reference

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TGF-beta and fibrosis in different organs - molecular pathway imprints

28 September 2017

1 reference

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BMP-7 as antagonist of organ fibrosis

28 September 2017

1 reference

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TGF-beta signaling in vascular biology and dysfunction

28 September 2017

1 reference

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Endoglin in angiogenesis and vascular diseases

28 September 2017

1 reference

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Extracellular control of TGFbeta signalling in vascular development and disease

28 September 2017

1 reference

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Transforming growth factor-beta and fibrosis

28 September 2017

1 reference

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Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on ERK1/2 MAPK activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Characterization of murine S-endoglin isoform and its effects on tumor development.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

28 September 2017

1 reference

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Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Role of endoglin in cellular responses to transforming growth factor-beta. A comparative study with betaglycan.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

A second locus for hereditary hemorrhagic telangiectasia maps to chromosome 12.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

The TGF beta receptor endoglin in systemic sclerosis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Mechanisms of tissue repair: from wound healing to fibrosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Increased intrahepatic and circulating levels of endoglin, a TGF-beta1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal fibrosis induced by renal mass reduction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3824608

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

28 November 2018

1 reference

12 December 2020

Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis

1 reference

12 December 2020

Localization of endoglin, a transforming growth factor-beta binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy

1 reference

12 December 2020

Potential biomarkers for detecting pulmonary arterial hypertension in patients with systemic sclerosis

1 reference

12 December 2020

A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease

1 reference

12 December 2020

Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line

1 reference

12 December 2020

Endoglin regulates renal ischaemia-reperfusion injury

1 reference

12 December 2020

Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts

1 reference

12 December 2020

The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions

1 reference

12 December 2020

Endoglin upregulation during experimental renal interstitial fibrosis in mice

1 reference

12 December 2020

Expression of endoglin in human mesangial cells: modulation of extracellular matrix synthesis

1 reference

12 December 2020

Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling

1 reference

12 December 2020

Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy

1 reference

12 December 2020

10.1016/B978-0-12-394308-8.00008-X

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

22608563

1 reference