DNA polymerase ε and its roles in genome stability (Q26822699)

language of work or name

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May 2014

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66

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PubMed

issue

5

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PubMed

page(s)

339-51

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PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication

PubMed

cites work

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Repriming of DNA synthesis at stalled replication forks by human PrimPol

21 January 2018

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PrimPol, an archaic primase/polymerase operating in human cells

21 January 2018

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Functions of DNA polymerases

21 January 2018

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DNA polymerases and cancer.

21 January 2018

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DNA polymerases and human disease

21 January 2018

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Balancing eukaryotic replication asymmetry with replication fidelity.

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon

21 January 2018

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Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase epsilon in DNA replication and the S/M checkpoint pathway

21 January 2018

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Analysis of the essential functions of the C-terminal protein/protein interaction domain of Saccharomyces cerevisiae pol epsilon and its unexpected ability to support growth in the absence of the DNA polymerase domain

21 January 2018

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Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

21 January 2018

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Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae

21 January 2018

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Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae

21 January 2018

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Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ɛ, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae.

21 January 2018

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Biochemical basis of DNA replication fidelity

21 January 2018

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DNA polymerase fidelity: kinetics, structure, and checkpoints

21 January 2018

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21 January 2018

DNA replication fidelity

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DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase

21 January 2018

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Analyzing fidelity of DNA polymerases.

21 January 2018

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Mutator phenotypes due to DNA replication infidelity.

21 January 2018

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The high fidelity and unique error signature of human DNA polymerase epsilon

21 January 2018

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Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.

21 January 2018

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Unique error signature of the four-subunit yeast DNA polymerase epsilon

21 January 2018

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Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex

21 January 2018

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Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases

21 January 2018

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Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta

21 January 2018

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Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

21 January 2018

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Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity

21 January 2018

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Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions.

21 January 2018

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High fidelity and lesion bypass capability of human DNA polymerase delta

21 January 2018

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Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication fork

21 January 2018

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Division of labor at the eukaryotic replication fork

21 January 2018

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Yeast DNA polymerase epsilon participates in leading-strand DNA replication

21 January 2018

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The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved

21 January 2018

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Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase

21 January 2018

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Distinctive activities of DNA polymerases during human DNA replication

21 January 2018

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Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts.

21 January 2018

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Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

21 January 2018

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Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

21 January 2018

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Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication.

21 January 2018

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Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication

21 January 2018

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Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

21 January 2018

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Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells

21 January 2018

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Further characterization of HeLa DNA polymerase epsilon

21 January 2018

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The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.

21 January 2018

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DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability

21 January 2018

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CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast

21 January 2018

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Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

21 January 2018

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Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication

21 January 2018

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DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast

21 January 2018

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The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability

21 January 2018

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Global identification of modular cullin-RING ligase substrates

21 January 2018

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Systematic and quantitative assessment of the ubiquitin-modified proteome

21 January 2018

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Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.

21 January 2018

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Causes and consequences of replication stress

21 January 2018

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Genome instability: a mechanistic view of its causes and consequences

21 January 2018

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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

21 January 2018

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Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks

21 January 2018

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The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement

21 January 2018

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Claspin promotes normal replication fork rates in human cells

21 January 2018

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Mrc1 transduces signals of DNA replication stress to activate Rad53.

21 January 2018

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Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

21 January 2018

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Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint

21 January 2018

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Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response

21 January 2018

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Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways.

21 January 2018

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

21 January 2018

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The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity

21 January 2018

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DNA polymerases and repair synthesis in NER in human cells

21 January 2018

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DNA polymerases required for repair of UV-induced damage in Saccharomyces cerevisiae

21 January 2018

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The roles of the eukaryotic DNA polymerases in DNA repair synthesis

21 January 2018

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Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

21 January 2018

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New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

21 January 2018

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Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae

21 January 2018

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Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

21 January 2018

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Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A

21 January 2018

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Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA.

21 January 2018

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

21 January 2018

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DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae

21 January 2018

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Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

21 January 2018

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Mammalian base excision repair by DNA polymerases delta and epsilon

21 January 2018

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Break-induced replication and genome stability.

21 January 2018

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Break-induced replication and telomerase-independent telomere maintenance require Pol32.

21 January 2018

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Increased mutagenesis and unique mutation signature associated with mitotic gene conversion

21 January 2018

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Break-induced replication is highly inaccurate

21 January 2018

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Break-induced replication repair of damaged forks induces genomic duplications in human cells.

21 January 2018

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Unlocking the sugar "steric gate" of DNA polymerases

21 January 2018

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Choosing the right sugar: how polymerases select a nucleotide substrate

21 January 2018

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Genome instability due to ribonucleotide incorporation into DNA.

21 January 2018

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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

21 January 2018

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RNase H2-initiated ribonucleotide excision repair.

21 January 2018

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Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA

21 January 2018

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Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

21 January 2018

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Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

21 January 2018

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A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability

21 January 2018

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Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides

21 January 2018

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Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines

21 January 2018

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Endonucleolytic function of MutLalpha in human mismatch repair.

21 January 2018

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Ribonucleotides are signals for mismatch repair of leading-strand replication errors

21 January 2018

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Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair

21 January 2018

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

21 January 2018

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Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

21 January 2018

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Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome

21 January 2018

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Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

21 January 2018

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Nucleic acid-mediated inflammatory diseases

21 January 2018

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Epigenetics: molecular mechanisms and implications for disease.

21 January 2018

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A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors

21 January 2018

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Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae

21 January 2018

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An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin

21 January 2018

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HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins

21 January 2018

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Coordination of DNA replication and histone modification by the Rik1-Dos2 complex

21 January 2018

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RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.

21 January 2018

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Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells

21 January 2018

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DNA polymerases at the eukaryotic fork-20 years later

21 January 2018

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The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae

21 January 2018

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DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice

21 January 2018

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High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading

21 January 2018

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Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer

21 January 2018

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A Crystallographic Study of the Role of Sequence Context in Thymine Glycol Bypass by a Replicative DNA Polymerase Serendipitously Sheds Light on the Exonuclease Complex

21 January 2018

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Comprehensive molecular characterization of human colon and rectal cancer

21 January 2018

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Integrated genomic characterization of endometrial carcinoma

21 January 2018

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Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

21 January 2018

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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

21 January 2018

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DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer

21 January 2018

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DNA polymerase proofreading: Multiple roles maintain genome stability

21 January 2018

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The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

21 January 2018

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Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers

21 January 2018

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From human genome to cancer genome: the first decade

21 January 2018

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Mutator suppression and escape from replication error-induced extinction in yeast

21 January 2018

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Antimutator variants of DNA polymerases

21 January 2018

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Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast

21 January 2018

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Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines

21 January 2018

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A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability

21 January 2018

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Polymerase delta variants in RER colorectal tumours

21 January 2018

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Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature ("FILS syndrome")

21 January 2018

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Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta

21 January 2018

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Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast

21 January 2018

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Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.

21 January 2018

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A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading

21 January 2018

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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

21 January 2018

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7 January 2021

DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication.

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7 January 2021

The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae

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7 January 2021

Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta

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7 January 2021

Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice

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7 January 2021

Identifiers

DOI

10.1002/IUB.1276

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Consolidated OpenCitations Corpus – April 2017

1551950

1551950

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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