Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift (Q26999365)

Crossref

C. Priolo

series ordinal

2

1 reference

Crossref

E. P. Henske

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

January 2015

1 reference

Molecular Cancer Research

published in

1 reference

volume

13

1 reference

issue

1

1 reference

page(s)

3-8

1 reference

Nutrient regulation of the mTOR complex 1 signaling pathway

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21 March 2017

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Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

21 March 2017

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CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

21 March 2017

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21 March 2017

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A complex interplay between Akt, TSC2 and the two mTOR complexes

21 March 2017

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

21 March 2017

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Tel2 regulates the stability of PI3K-related protein kinases

21 March 2017

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 March 2017

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Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition

21 March 2017

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TSC2 mediates cellular energy response to control cell growth and survival

21 March 2017

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

21 March 2017

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Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC)

21 March 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 March 2017

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The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

21 March 2017

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Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1

21 March 2017

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MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1

21 March 2017

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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

21 March 2017

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Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

21 March 2017

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 March 2017

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The tuberous sclerosis complex

7 April 2017

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High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.

7 April 2017

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mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

28 September 2017

1 reference

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The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism

28 September 2017

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Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells

28 September 2017

1 reference

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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide

28 September 2017

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A growing role for mTOR in promoting anabolic metabolism

28 September 2017

1 reference

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

28 September 2017

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Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma

28 September 2017

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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

28 September 2017

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Low glycemic index treatment for epilepsy in tuberous sclerosis complex

28 September 2017

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Glucose deprivation in tuberous sclerosis complex-related tumors

28 September 2017

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Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress.

28 September 2017

1 reference

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Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

28 September 2017

1 reference

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Relieving autophagy and 4EBP1 from rapamycin resistance

28 September 2017

1 reference

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Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

28 September 2017

1 reference

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mTOR links oncogenic signaling to tumor cell metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Tuberous sclerosis complex and the ketogenic diet

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Alkylating DNA damage stimulates a regulated form of necrotic cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Power of rare diseases: found in translation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

A metabolic (re-)balancing act.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4312527

10.1158/1541-7786.MCR-14-0343

28 November 2018

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

25298408

1 reference