A growing role for mTOR in promoting anabolic metabolism (Q38122221)

29 August 2017

A growing role for mTOR in promoting anabolic metabolism (English)

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29 August 2017

Jessica J Howell

1

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29 August 2017

Stéphane J H Ricoult

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2

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29 August 2017

Issam Ben-Sahra

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3

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29 August 2017

Brendan D Manning

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4

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29 August 2017

1 August 2013

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Biochemical Society Transactions

29 August 2017

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29 August 2017

41

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29 August 2017

906-912

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29 August 2017

4

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Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

29 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Common corruption of the mTOR signaling network in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Nutrient signaling to mTOR and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Synthesis of the translational apparatus is regulated at the translational level

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

A unifying model for mTORC1-mediated regulation of mRNA translation.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

RNA polymerases I and III, growth control and cancer

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

The multifaceted role of mTORC1 in the control of lipid metabolism

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Role of S6K1 in regulation of SREBP1c expression in the liver

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Regulation of carbamoyl phosphate synthetase by MAP kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Increased lipogenesis in cancer cells: new players, novel targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Statin use and reduced cancer-related mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Cholesterol, statins and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

G1 events and regulation of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Does the ribosome translate cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

The translational landscape of mTOR signalling steers cancer initiation and metastasis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

The pharmacology of mTOR inhibition

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20130041

Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130041

21 January 2018

Identifiers

DOI

10.1042/BST20130041

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29 August 2017

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