Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome (Q28307704)

7

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author name string

Suchithra Menon

1

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George Talbott

3

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Gerta Hoxhaj

4

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Alexander J Valvezan

5

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Hidenori Takahashi

6

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Brendan D Manning

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations

8

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language of work or name

English

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publication date

13 February 2014

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published in

Cell

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volume

156

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page(s)

771-85

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issue

4

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cites work

1 reference

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

20 March 2017

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

20 March 2017

1 reference

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

20 March 2017

1 reference

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mTOR signaling in growth control and disease

20 March 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

20 March 2017

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

20 March 2017

1 reference

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GEFs and GAPs: critical elements in the control of small G proteins

20 March 2017

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

20 March 2017

1 reference

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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

20 March 2017

1 reference

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

20 March 2017

1 reference

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Localization of Rheb to the endomembrane is critical for its signaling function

20 March 2017

1 reference

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AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

20 March 2017

1 reference

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Rheb binds and regulates the mTOR kinase

20 March 2017

1 reference

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The GTPase-activating protein Rap1GAP uses a catalytic asparagine

20 March 2017

1 reference

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

20 March 2017

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

20 March 2017

1 reference

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

20 March 2017

1 reference

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

20 March 2017

1 reference

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The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

20 March 2017

1 reference

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A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

20 March 2017

1 reference

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Regulation of TORC1 by Rag GTPases in nutrient response

7 April 2017

1 reference

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

The tuberous sclerosis complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

A growing role for mTOR in promoting anabolic metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Common corruption of the mTOR signaling network in human tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Tsc2 is not a critical target of Akt during normal Drosophila development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Lysosomal positioning coordinates cellular nutrient responses.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Functional assessment of TSC2 variants identified in individuals with tuberous sclerosis complex.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030681

Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24529379

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2013.11.049

1 reference

907790

907790

1 reference

1 reference

1 reference