Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target? (Q27013585)

T Chen

series ordinal

2

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language of work or name

1 reference

April 2014

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British Journal of Pharmacology

published in

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volume

171

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issue

8

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page(s)

2191-205

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Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels

cites work

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Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

21 March 2017

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VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

21 March 2017

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 March 2017

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 March 2017

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 March 2017

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Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1(G93A) mice model

21 March 2017

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Exome sequencing reveals VCP mutations as a cause of familial ALS

21 March 2017

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TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

21 March 2017

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SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

21 March 2017

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A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

21 March 2017

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ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

21 March 2017

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Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 March 2017

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Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

21 March 2017

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FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration

21 March 2017

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 March 2017

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The complex molecular biology of amyotrophic lateral sclerosis (ALS)

21 March 2017

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 March 2017

1 reference

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Mitochondrial fragmentation in neurodegeneration

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

21 March 2017

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TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 March 2017

1 reference

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS

7 April 2017

1 reference

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The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Functions of BCL-X L at the Interface between Cell Death and Metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

The changing scene of amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Controversies and priorities in amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

AIF, reactive oxygen species, and neurodegeneration: a "complex" problem

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mitochondria: master regulators of danger signalling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse

28 September 2017

1 reference

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Physiological roles of the permeability transition pore

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mitochondrial pathobiology in ALS.

28 September 2017

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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: examining a more efficient trial design

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Bcl2-A1 interacts with pro-caspase-3: implications for amyotrophic lateral sclerosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Caspase-8 and bid: caught in the act between death receptors and mitochondria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity.

28 September 2017

1 reference

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Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS

28 September 2017

1 reference

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Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.

28 September 2017

1 reference

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Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

28 September 2017

1 reference

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Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

28 September 2017

1 reference

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Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis.

28 September 2017

1 reference

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Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions

28 September 2017

1 reference

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ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

28 September 2017

1 reference

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Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

28 September 2017

1 reference

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Mitochondria, oxidative metabolism and cell death in stroke

28 September 2017

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The human G93A-superoxide dismutase-1 mutation, mitochondrial glutathione and apoptotic cell death

28 September 2017

1 reference

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The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice

28 September 2017

1 reference

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Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.

28 September 2017

1 reference

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Targeting post-mitochondrial effectors of apoptosis for neuroprotection

28 September 2017

1 reference

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ALS and FTLD: two faces of TDP-43 proteinopathy

28 September 2017

1 reference

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Motor neuron disease: The curious ways of ALS

28 September 2017

1 reference

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Complex I and energy thresholds in the brain

28 September 2017

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Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants

28 September 2017

1 reference

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Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

28 September 2017

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Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

28 September 2017

1 reference

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Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

28 September 2017

1 reference

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A century-old debate on protein aggregation and neurodegeneration enters the clinic

28 September 2017

1 reference

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Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials.

28 September 2017

1 reference

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Transgenic mouse models of amyotrophic lateral sclerosis

28 September 2017

1 reference

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Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Glutaredoxin: role in reversible protein s-glutathionylation and regulation of redox signal transduction and protein translocation

28 September 2017

1 reference

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A clinical trial of creatine in ALS.

28 September 2017

1 reference

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Mitochondrial glutathione: a modulator of brain cell death

28 September 2017

1 reference

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S-glutathionylation: from redox regulation of protein functions to human diseases.

28 September 2017

1 reference

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Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials

28 September 2017

1 reference

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Mitochondrial control of neuron death and its role in neurodegenerative disorders.

28 September 2017

1 reference

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Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid

28 September 2017

1 reference

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Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis

28 September 2017

1 reference

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Oxidatively modified proteins in aging and disease

28 September 2017

1 reference

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Superoxide dismutase and the death of motoneurons in ALS.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Metabolism and functions of glutathione in brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

28 September 2017

Riluzole and ALS therapy

1 reference

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Mitochondrial changes associated with glutathione deficiency

28 September 2017

1 reference

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Origin and turnover of mitochondrial glutathione

28 September 2017

1 reference

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Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis

28 September 2017

1 reference

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A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity

31 May 2018

1 reference

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Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mitochondrial respiratory chain function in skeletal muscle of ALS patients.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mitochondrial control of apoptosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane

31 May 2018

1 reference

Glutathione monoethyl ester provides neuroprotection in a rat model of stroke.

21 January 2018

1 reference

Immunosuppressant FK506 does not exert beneficial effects in symptomatic G93A superoxide dismutase-1 transgenic mice.

21 January 2018

1 reference

Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity.

21 January 2018

1 reference

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis

21 January 2018

1 reference

A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis

21 January 2018

1 reference

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

21 January 2018

1 reference

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells.

21 January 2018

1 reference

Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis

21 January 2018

1 reference

Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

Intrathecal cyclosporin prolongs survival of late-stage ALS mice

21 January 2018

1 reference

Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice.

21 January 2018

1 reference

Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival

21 January 2018

1 reference

Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.

21 January 2018

1 reference

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

21 January 2018

1 reference

Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment

21 January 2018

1 reference

Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene

21 January 2018

1 reference

Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture

21 January 2018

1 reference

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model

21 January 2018

1 reference

Decreased mRNA expression of PGC-1α and PGC-1α-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS.

21 January 2018

1 reference

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

Mitochondrial Glutathione: Importance and Transport

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

21 January 2018

Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: Subgroup analysis of demographic and clinical characteristics

28 November 2018

1 reference

Pathophysiological implications of mithochondrial cell death control.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3976630

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

28 November 2018

1 reference

12 December 2020

Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam

1 reference

12 December 2020

Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

1 reference

12 December 2020

Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

12 December 2020

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

1 reference

12 December 2020

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

1 reference

12 December 2020

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

1 reference

12 December 2020

Mitochondrial glutathione protects against cell death induced by oxidative and nitrative stress in astrocytes

1 reference

12 December 2020

Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Deleterious role of superoxide dismutase in the mitochondrial intermembrane space

1 reference

12 December 2020

Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

1 reference

12 December 2020

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

12 December 2020

Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis

1 reference

12 December 2020

Mitochondrial alterations in dorsal root ganglion cells in sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

1 reference

12 December 2020

Identifiers

0 references

1 reference

PubMed publication ID

24148000

1 reference