Ageing and Parkinson's disease: why is advancing age the biggest risk factor? (Q27021628)

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7 March 2020

1 reference

8 October 2022

Ageing and Parkinson's disease: why is advancing age the biggest risk factor? (English)

1 reference

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7 March 2020

5 references

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20 August 2019

12 September 2019

12 October 2019

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physiological phenomenon

1 reference

20 August 2019

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12 September 2019

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12 October 2019

Douglass Matthew Turnbull

series ordinal

3

1 reference

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7 March 2020

author name string

Amy Reeve

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1

2 references

Crossref

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7 March 2020

Eve Simcox

series ordinal

2

2 references

Crossref

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language of work or name

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3 February 2014

1 reference

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7 March 2020

1 March 2014

1 reference

8 October 2022

Ageing Research Reviews

7 references

25 April 2019

20 August 2019

12 September 2019

12 October 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24503004%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

8 October 2022

14

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7 March 2020

page(s)

19-30

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Creative Commons Attribution 3.0 Unported

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copyright license

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on focus list of Wikimedia project

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cites work

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

21 March 2017

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

7 April 2017

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Epidemiology of Parkinson's disease

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

7 April 2017

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Stages in the development of Parkinson's disease-related pathology

7 April 2017

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

7 April 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 April 2017

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Ageing and Parkinson's disease: substantia nigra regional selectivity

7 April 2017

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The function of α-synuclein

7 April 2017

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Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms

28 September 2017

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Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease

28 September 2017

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HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.

28 September 2017

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The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

28 September 2017

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Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.

28 September 2017

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The pathology roadmap in Parkinson disease

28 September 2017

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28 September 2017

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α-Synuclein oligomers and clinical implications for Parkinson disease

28 September 2017

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Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

28 September 2017

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28 September 2017

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28 September 2017

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Lewy pathology and neurodegeneration in premotor Parkinson's disease

28 September 2017

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28 September 2017

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Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

28 September 2017

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Nigral pathology and parkinsonian signs in elders without Parkinson disease

28 September 2017

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28 September 2017

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Cerebellar ataxia in patients with mitochondrial DNA disease: a molecular clinicopathological study

28 September 2017

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Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

28 September 2017

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Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease

28 September 2017

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Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

28 September 2017

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Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics

28 September 2017

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Α-synuclein misfolding and Parkinson's disease

28 September 2017

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Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease.

28 September 2017

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MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping

28 September 2017

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28 September 2017

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Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder.

28 September 2017

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Milestones in PD genetics

28 September 2017

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

28 September 2017

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The role of α-synuclein in neurotransmission and synaptic plasticity

28 September 2017

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28 September 2017

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

28 September 2017

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Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

28 September 2017

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Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults

28 September 2017

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Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances

28 September 2017

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POLG1 polyglutamine tract variants associated with Parkinson's disease

28 September 2017

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Mitochondrial DNA mutations affect calcium handling in differentiated neurons

28 September 2017

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Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

28 September 2017

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The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

28 September 2017

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Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

28 September 2017

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

28 September 2017

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Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling

28 September 2017

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Mitochondrial association of alpha-synuclein causes oxidative stress

28 September 2017

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What causes mitochondrial DNA deletions in human cells?

28 September 2017

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Morphometry of the human substantia nigra in ageing and Parkinson's disease

28 September 2017

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The comparative biology of neuromelanin and lipofuscin in the human brain

28 September 2017

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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

28 September 2017

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Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient

28 September 2017

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Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

28 September 2017

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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

28 September 2017

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Understanding the molecular causes of Parkinson's disease.

28 September 2017

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Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy

28 September 2017

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Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

28 September 2017

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Mitochondrial DNA mutations in human colonic crypt stem cells

28 September 2017

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Alzheimer's disease and Parkinson's disease

28 September 2017

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Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

28 September 2017

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

28 September 2017

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Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

28 September 2017

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The pedunculopontine nucleus and Parkinson's disease

28 September 2017

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The role of the locus coeruleus in the development of Parkinson's disease

28 September 2017

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Nigral and extranigral pathology in Parkinson's disease.

28 September 2017

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Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy

28 September 2017

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Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease

28 September 2017

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The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease

28 September 2017

1 reference

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The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

31 May 2018

1 reference

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Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

31 May 2018

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Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

31 May 2018

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Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript

31 May 2018

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Cytochrome c oxidase defects of the human substantia nigra in normal aging

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Neocortical neuron number in humans: effect of sex and age.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitochondrial complex I deficiency in Parkinson's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Number of CAG repeats in POLG1 and its association with Parkinson disease in the Norwegian population

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Relationship between mitochondria and α-synuclein: a study of single substantia nigra neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Variations of the CAG trinucleotide repeat in DNA polymerase γ (POLG1) is associated with Parkinson's disease in Sweden

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Neuropathology of dementia with Lewy bodies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Parkinson syndrome, neuropathy, and myopathy caused by the mutation A8344G (MERRF) in tRNALys

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Morphological alterations of the synapses in the locus coeruleus in Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Early-onset familial parkinsonism due to POLG mutations

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

A novel polymerase gamma mutation in a family with ophthalmoplegia, neuropathy, and Parkinsonism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Axonal mitochondrial transport and potential are correlated

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Iron-binding characteristics of neuromelanin of the human substantia nigra.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Altered proteasomal function in sporadic Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Proteasomal function is impaired in substantia nigra in Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3989046

Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study

28 November 2018

1 reference

12 December 2020

1 reference

12 December 2020

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

1 reference

12 December 2020

Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1 reference

12 December 2020

Mutation of the linker region of the polymerase gamma-1 (POLG1) gene associated with progressive external ophthalmoplegia and Parkinsonism

1 reference

12 December 2020

Mitochondrial DNA polymorphisms and haplogroups in Parkinson's disease and control individuals with a similar genetic background

1 reference

12 December 2020

Iron as a trigger of neurodegeneration in Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

12 December 2020

Mitochondrial myopathy, parkinsonism, and multiple mtDNA deletions in a Sephardic Jewish family

1 reference

12 December 2020

Evidence for specific phases in the development of human neuromelanin

1 reference

12 December 2020

10.1016/J.ARR.2014.01.004

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24503004%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24503004%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

24503004

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24503004%20AND%20SRC:MED&resulttype=core&format=json