Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice (Q27308060)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25836420%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice (English)

1 reference

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4 March 2020

1 reference

1 reference

5

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4 March 2020

Wolfdieter Springer

17

1 reference

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4 March 2020

Matthew J. Farrer

19

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4 March 2020

18

D W Dickson

1 reference

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4 March 2020

author name string

M Yue

1

1 reference

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4 March 2020

K M Hinkle

2

1 reference

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4 March 2020

P Davies

3

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4 March 2020

E Trushina

4

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4 March 2020

T A Christenson

6

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4 March 2020

A S Schroeder

7

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4 March 2020

L Zhang

8

1 reference

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4 March 2020

E Bowles

9

1 reference

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4 March 2020

B Behrouz

10

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4 March 2020

S J Lincoln

11

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4 March 2020

J E Beevers

12

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4 March 2020

A J Milnerwood

13

1 reference

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4 March 2020

A Kurti

14

1 reference

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4 March 2020

P J McLean

15

1 reference

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4 March 2020

J D Fryer

16

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4 March 2020

H L Melrose

20

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4 March 2020

language of work or name

English

0 references

publication date

31 March 2015

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4 March 2020

published in

Neurobiology of Disease

1 reference

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4 March 2020

volume

78

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4 March 2020

page(s)

172-195

1 reference

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LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

4 March 2020

cites work

1 reference

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Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

21 March 2017

1 reference

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LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

21 March 2017

1 reference

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Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies

21 March 2017

1 reference

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Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

21 March 2017

1 reference

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LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

21 March 2017

1 reference

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Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

21 March 2017

1 reference

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Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis

21 March 2017

1 reference

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Interplay of LRRK2 with chaperone-mediated autophagy

21 March 2017

1 reference

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Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

21 March 2017

1 reference

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Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation

21 March 2017

1 reference

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LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

21 March 2017

1 reference

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LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

21 March 2017

1 reference

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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

21 March 2017

1 reference

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G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

21 March 2017

1 reference

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Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

21 March 2017

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Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

21 March 2017

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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

21 March 2017

1 reference

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Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease

21 March 2017

1 reference

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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

21 March 2017

1 reference

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Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

21 March 2017

1 reference

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 March 2017

1 reference

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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

21 March 2017

1 reference

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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 March 2017

1 reference

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Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

21 March 2017

1 reference

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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 March 2017

1 reference

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 March 2017

1 reference

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

21 March 2017

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 March 2017

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Inhibition of LRRK2 kinase activity stimulates macroautophagy

21 March 2017

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 March 2017

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Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease

21 March 2017

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Mechanisms of neurotransmitter release by amphetamines: a review

21 March 2017

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 March 2017

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

21 March 2017

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 March 2017

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Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

7 April 2017

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Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats

28 September 2017

1 reference

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The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

28 September 2017

1 reference

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Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

28 September 2017

1 reference

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Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

28 September 2017

1 reference

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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

28 September 2017

1 reference

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Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

28 September 2017

1 reference

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LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

28 September 2017

1 reference

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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

28 September 2017

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Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice

28 September 2017

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Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

28 September 2017

1 reference

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Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy.

28 September 2017

1 reference

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Amphetamine paradoxically augments exocytotic dopamine release and phasic dopamine signals

28 September 2017

1 reference

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Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2.

28 September 2017

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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

28 September 2017

1 reference

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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

28 September 2017

1 reference

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Regulation of physiologic actions of LRRK2: focus on autophagy

28 September 2017

1 reference

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Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons

28 September 2017

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Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

28 September 2017

1 reference

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

28 September 2017

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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

28 September 2017

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Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

28 September 2017

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DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease

28 September 2017

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In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery

28 September 2017

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

28 September 2017

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

28 September 2017

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

28 September 2017

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MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease

28 September 2017

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Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

28 September 2017

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Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

28 September 2017

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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

28 September 2017

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

28 September 2017

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

28 September 2017

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

28 September 2017

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LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study

28 September 2017

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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Mitochondrial dysfunction, oxidative stress, regulation of exocytosis and their relevance to neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Increase in dopamine turnover occurs early in Parkinson's disease: evidence from a new modeling approach to PET 18 F-fluorodopa data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Pharmacology of mesocortical dopamine neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Dopamine release and metabolism in the rat striatum: an analysis by 'in vivo' brain microdialysis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

An in vivo study of dopamine release and metabolism in rat brain regions using intracerebral dialysis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs; implications for the origin of extracellular DOPAC.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Effect of dopamine D-1 and D-2 receptor selective drugs on dopamine release and metabolism in rat striatum in vivo

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: possible significance in the transgenic model mouse of Parkinson's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 expression is enriched in the striosomal compartment of mouse striatum

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Regulation of presynaptic neurotransmission by macroautophagy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 and human disease: a complicated question or a question of complexes?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Dopamine turnover increases in asymptomatic LRRK2 mutations carriers

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Sequence and significance of dopamine metabolism in the rat brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Lrrk2 and alpha-synuclein are co-regulated in rodent striatum

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Distribution of PINK1 and LRRK2 in rat and mouse brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 expression linked to dopamine-innervated areas

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: their relation to disease-compensatory mechanisms

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4526103

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25836420

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Simple screening procedure to detect gene targeting events in embryonic stem cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25836420

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2015.02.031

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25836420%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

4 March 2020

1574838

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1574838

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25836420%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

PubMed publication ID

25836420

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25836420%20AND%20SRC:MED&resulttype=core&format=json