A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion (Q27314498)

Insulin-like peptide 2 Dmel_CG8167

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Insulin-like receptor Dmel_CG18402

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Akt1 Dmel_CG4006

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1 reference

Sangbin Park

1

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Ronald W Alfa

2

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Sydni M Topper

3

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Grace E S Kim

4

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Lutz Kockel

5

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Seung K Kim

Creative Commons Attribution 4.0 International

6

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language of work or name

English

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publication date

August 2014

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published in

PLOS Genetics

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volume

10

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page(s)

e1004555

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issue

8

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copyright license

start time

7 August 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling

21 March 2017

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Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation

21 March 2017

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A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size

21 March 2017

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A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

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Quantifying Drosophila food intake: comparative analysis of current methodology

7 April 2017

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Diabetes mellitus due to the toxic misfolding of proinsulin variants

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Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults

28 September 2017

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Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion

28 September 2017

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Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

28 September 2017

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Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster

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Molecular evolution and functional characterization of Drosophila insulin-like peptides

28 September 2017

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Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

28 September 2017

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A screen for modifiers of notch signaling uncovers Amun, a protein with a critical role in sensory organ development

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Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance.

28 September 2017

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Insulin resistance and pancreatic beta cell failure

28 September 2017

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From mice to men: insights into the insulin resistance syndromes

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Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase

28 September 2017

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Glucose increases activity and Ca2+ in insulin-producing cells of adult Drosophila

28 September 2017

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The Drosophila glucose transporter gene: cDNA sequence, phylogenetic comparisons, analysis of functional sites and secondary structures

31 May 2018

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The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women.

31 May 2018

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Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes

31 May 2018

1 reference

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Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Remote control of insulin secretion by fat cells in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide

21 January 2018

1 reference

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An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Impairment of the priming effect of glucose on insulin secretion from isolated islets of aging rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Genetic analysis of protein kinase B (AKT) in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

A targeted gain of function screen in the embryonic CNS of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004555

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

21 January 2018

1 reference

12 December 2020

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1 reference

12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

12 December 2020

A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

1 reference

12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1004555

Identifiers

DOI

1 reference

release_f3hditadgjgpjkre3nunk6vog4

1479262

Fatcat ID

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1479262

1 reference

1 reference

1 reference