Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain (Q27317421)

26 June 2017

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain (English)

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26 June 2017

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Julia F Alterman

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26 June 2017

Lauren M Hall

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26 June 2017

Andrew H Coles

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26 June 2017

Matthew R Hassler

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26 June 2017

Marie-Cecile Didiot

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26 June 2017

Kathryn Chase

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26 June 2017

Jasmin Abraham

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26 June 2017

Emily Sottosanti

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26 June 2017

Emily Johnson

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26 June 2017

Ellen Sapp

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26 June 2017

Maire F Osborn

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26 June 2017

Marian Difiglia

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26 June 2017

Neil Aronin

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26 June 2017

Anastasia Khvorova

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26 June 2017

language of work or name

English

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publication date

1 December 2015

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Molecular Therapy. Nucleic acids

26 June 2017

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4

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page(s)

e266

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describes a project that uses

26 June 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5014532/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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21 March 2017

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21 March 2017

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 March 2017

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Functional siRNAs and miRNAs Exhibit Strand Bias

21 March 2017

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21 March 2017

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Silencing disease genes in the laboratory and the clinic

21 March 2017

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

7 April 2017

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Rational siRNA design for RNA interference

7 April 2017

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Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

7 April 2017

1 reference

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Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

28 September 2017

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In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.

28 September 2017

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Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7.

28 September 2017

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Novel hydrophobically modified asymmetric RNAi compounds (sd-rxRNA) demonstrate robust efficacy in the eye.

28 September 2017

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FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver

28 September 2017

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Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Designing chemically modified oligonucleotides for targeted gene silencing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

28 September 2017

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Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo

28 September 2017

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Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin

28 September 2017

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Transfection techniques for neuronal cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Inflammatory neurodegeneration and mechanisms of microglial killing of neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Comparison of different commercially available cationic liposome-DNA lipoplexes: Parameters influencing toxicity and transfection efficiency.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Chemically modified siRNA: tools and applications.

28 September 2017

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Identifying siRNA-induced off-targets by microarray analysis

28 September 2017

1 reference

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28 September 2017

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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

28 September 2017

1 reference

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Transvascular delivery of small interfering RNA to the central nervous system.

28 September 2017

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Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

28 September 2017

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RNA interference in neuroscience: progress and challenges

28 September 2017

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Activation of the mammalian immune system by siRNAs.

28 September 2017

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Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

28 September 2017

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Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

28 September 2017

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Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo

28 September 2017

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RNA interference: listening to the sound of silence

28 September 2017

1 reference

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Liposomal transfection efficiency and toxicity on glioma cell lines: in vitro and in vivo studies

28 September 2017

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A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

28 September 2017

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Polyion complex micelles composed of pegylated polyasparthydrazide derivatives for siRNA delivery to the brain

28 September 2017

1 reference

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Age-dependent microglial activation in immature brains after hypoxia- ischemia

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Construction of shRNA lentiviral vector

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Rapid microglial activation induced by traumatic brain injury is independent of blood brain barrier disruption.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Use of adeno-associated viral vector for delivery of small interfering RNA.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014532

Developmental and cell type-specific expression of the neuronal marker NeuN in the murine cerebellum.

28 November 2018

1 reference

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Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications

28 November 2018

1 reference

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DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.

28 November 2018

1 reference

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A protocol for designing siRNAs with high functionality and specificity

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26623938

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Widespread suppression of huntingtin with convection-enhanced delivery of siRNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26623938

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MTNA.2015.38

1 reference

OpenCitations bibliographic resource ID

26 June 2017

4190292

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference